Table 5.
In vivo hepatoprotective study by paracetamol model on various biochemical parameters.
| Name of group | AST (IU/L) | ALT (IU/L) | ALP (IU/L) | Total bilirubin (mg/dL) |
|---|---|---|---|---|
| Normal | 64.90 ± 2.941 | 43.87 ± 2.496 | 150.3 ± 5.004 | 0.5580 ± 0.03441 |
| Paracetamol-treated group | 139.7 ± 1.732∗∗∗# | 95.93 ± 8.108∗∗∗# | 294.0 ± 13.55∗∗∗# | 1.490 ± 0.04012∗∗∗# |
| Silymarin treated | 89.01 ± 1.790∗∗a | 45.27 ± 4.737∗∗a | 171.8 ± 1.743∗∗a | 0.6440 ± 0.03092∗∗a |
| SSD (1 : 1) | 133.2 ± 1.132∗∗b | 76.01 ± 2.843∗b | 256.7 ± 3.839∗∗a | 0.9800 ± 0.005477∗∗a |
| SSD (1 : 2) | 119.1 ± 1.870∗∗a | 66.87 ± 3.418∗∗a | 245.7 ± 7.042∗∗a | 0.9060 ± 0.02839∗∗a |
| SSD (1 : 3) | 97.14 ± 0.8002∗∗a | 54.79 ± 3.859∗∗a | 196.6 ± 1.886∗∗a | 0.7300 ± 0.01517∗∗a |
Values are expressed as mean ± SEM. ∗∗∗#p < 0.0001 compared with control by the Student unpaired “t”-test; ∗bp < 0.05 compared with paracetamol; ∗∗ap < 0.001 compared with paracetamol.