Table 3:
Model AUC values
| AUC value | |||||
|---|---|---|---|---|---|
| Model | All observed data | Randomly sampling one biopsy | Randomly sampling one area per core biopsy | Randomly adding HER2 copies | |
| Classification based on the fraction of HER2 non-amplified cells | All patients | 0.62 | 0.63 (0.60–0.66) |
0.61 (0.56–0.65) |
-- |
| HR+ | 0.59 | 0.61 (0.57–0.65) |
0.60 (0.54–0.66) |
-- | |
| HR− | 0.75 | 0.72 (0.67–0.77) |
0.69 (0.61–0.77) |
-- | |
| Logistic regression | Model 1 | 0.70 | 0.69 (0.66–0.72) |
0.68 (0.65–0.72) |
0.69 (0.65–0.72) |
| Model 2 | 0.65 | 0.65 (0.64–0.67) |
0.65 (0.64–0.68) |
-- | |
| Model 3 | 0.70 | 0.69 (0.67–0.72) |
0.68 (0.65–0.72) |
-- | |
| Model 4 | 0.71 | 0.69 (0.66–0.72) |
0.68 (0.65–0.72) |
-- | |
| Model 5 | 0.72 | 0.72 (0.69–0.75) |
0.71 (0.68–0.75) |
-- | |
| Model 6 | 0.71 | 0.70 (0.68–0.73) |
0.70 (0.66–0.73) |
-- | |
| Model 7 | 0.69 | 0.69 (0.67–0.71) |
0.69 (0.66–0.72) |
-- | |