Table 2.
Multivariable Logistic Regression Models of 7-Day All-Cause Mortality in the Derivation Population (n = 8808)
| Variables | PBSa | BSIMRSb | ED-BMc |
|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Age | |||
| <65 y | Reference | ||
| 65–84 y | 0.95 (0.78–1.17) | ||
| ≥85 y | 1.55 (1.13–2.14) | ||
| Ear temperature | |||
| 36.1°C–38.9°C | Reference | Reference | Reference |
| 35.1°C–36.0°C or 39.0°C–39.9°C | 0.91 (0.74–1.11) | 0.95 (0.77–1.17) | 0.92 (0.74–1.14) |
| ≤35.0°C or ≥ 40.0°C | 0.82 (0.61–1.11) | 0.94 (0.68–1.28) | 1.02 (0.73–1.42) |
| Hypotension | 4.00 (3.23–4.95) | 3.76 (3.03–4.68) | 2.74 (2.18–3.44) |
| Mechanical ventilation | 1.92 (1.57–2.36) | 1.90 (1.54–2.36) | 1.58 (1.26–1.98) |
| Cardiac arrest | 6.43 (5.04–8.20) | 6.53 (5.07–8.40) | 7.29 (5.57–9.56) |
| Mental status | |||
| Alert (GCS 15) | Reference | Reference | Reference |
| Disoriented (GCS 9–14) | 2.46 (1.98–3.04) | 2.45 (1.97–3.06) | 1.81 (1.43–2.29) |
| Stuporous (GCS 4–8) | 2.35 (1.76–3.14) | 2.48 (1.83–3.34) | 1.90 (1.37–2.62) |
| Comatose (GCS 3) | 4.75 (3.37–6.70) | 4.98 (3.50–7.07) | 3.62 (2.50–5.24) |
| Cancer | 3.24 (2.66–3.94) | 2.58 (2.07–3.23) | |
| Liver cirrhosis | 1.55 (1.15–2.09) | 1.11 (0.81–1.53) | |
| Infection source | |||
| Genitourinary | Reference | Reference | |
| Nongenitourinary or CVC | 2.61 (2.03–3.36) | 2.62 (2.01–3.41) | |
| Steroid use | 1.62 (1.26–2.10) | ||
| eGFR <45mL/min/1.73 m2 | 1.53 (1.19–1.97) | ||
| Platelet <100 ×103/μL | 2.14 (1.75–2.61) | ||
| BUN >30mg/dL | 2.29 (1.78–2.94) | ||
| RDW >14.5% | 1.47 (1.19–1.81) | ||
| Serum potassium <4.0 mmol/L | 0.70 (0.58–0.86) | ||
| Hemoglobin <11.5g/dL | 1.17 (0.95–1.44) | ||
| Model performance | |||
| AIC | 3579.948 | 3533.314 | 3228.458 |
| AUC (95% CI) | 0.850 (0.835–0.865) | 0.883 (0.871–0.895) | 0.909 (0.900–0.919) |
| P difference in AUC | <.0001 | <.0001 | Reference |
Abbreviations: AIC, Akaike information criterion; AUC, area under curve; BSIMRS, Bloodstream Infection Mortality Risk Score; BUN, blood urea nitrogen; CVC, central venous catheter; ED-BM, emergency department bacteremia mortality model; eGFR, estimated glomerular filtration rate; GCS, Glasgow Coma Scale; OR, odds ratio; PBS, Pitt Bacteremia Score; RDW, red cell distribution width.
PBS model included temperature, hypotension, mechanical ventilation, cardiac arrest, and mental status.
BSIMRS model included components of PBS, cancer, liver cirrhosis, and infection source.
ED-BM model included components of PBS and BSIRMS, age, cancer, liver cirrhosis, infection source, eGFR, platelet, BUN, RDW, serum potassium, and hemoglobin.