Table 4.
Univariate and multivariate Cox regression for Mortality
| Variables | Patients with hypertension | |||
|---|---|---|---|---|
| 95% IC | ||||
| HR | Lower | Upper | P value | |
| Univariate cox regression for mortality | ||||
| Age, years, ±SD | 1,051 | 1,038 | 1,063 | 0.001 |
| Female sex | 0,654 | 0,484 | 0,844 | 0.006 |
| Diabetes | 1,391 | 1,056 | 1,831 | 0.019 |
| Creatinine, mg/dl | 1,366 | 1,247 | 1,496 | 0.001 |
| Coronary calcium volume, mm3 | 1,001 | 1,000 | 1,001 | 0.003 |
| Lung interstitial involvement, n/N | 1,2 | 1,034 | 1,408 | 0.017 |
| Multivariate cox regression for mortality (coronary calcium volume) | ||||
| Age, years, ±SD | 1,045 | 1,032 | 1,058 | 0.001 |
| Female sex | 0,695 | 0,504 | 0,958 | 0.026 |
| Diabetes | 1,289 | 0,973 | 1,707 | 0.077 |
| Creatinine, mg/dl | 1,239 | 1,121 | 1,370 | 0.001 |
| Coronary calcium volume, mm3 | 1,001 | 1,000 | 1,001 | 0.001 |
| Lung interstitial involvement, n/N | 1,216 | 1,037 | 1,425 | 0.016 |
| Multivariate cox regression for mortality (coronary calcium volume > 100) | ||||
| Age, years, ±SD | 1,048 | 1,035 | 1,061 | 0.001 |
| Female sex | 0,705 | 0,511 | 0,972 | 0.033 |
| Diabetes | 1,296 | 0,978 | 1,717 | 0.071 |
| Creatinine, mg/dl | 1,231 | 1,114 | 1,361 | 0.001 |
| Coronary calcium volume >100, mm3 | 1,345 | 1,029 | 1,757 | 0.030 |
| Lung interstitial involvement, n/N | 1,204 | 1,027 | 1,411 | 0.022 |
| Multivariate cox regression for mortality (coronary calcium volume > 400) | ||||
| Age, years, ±SD | 1,047 | 1,034 | 1,060 | 0.001 |
| Female sex | 0,698 | 0,506 | 0,962 | 0.028 |
| Diabetes | 1,280 | 0,966 | 1,696 | 0.085 |
| Creatinine, mg/dl | 1,242 | 1,123 | 1,373 | 0.001 |
| Coronary calcium volume >400, mm3 | 1,315 | 1,010 | 1,713 | 0.042 |
| Lung interstitial involvement, n/N | 1,214 | 1,036 | 1,422 | 0.016 |
| Multivariate cox regression for mortality (coronary calcium volume ordinal variabile for every 100 mm3) | ||||
| Age, years, ±SD | 1,044 | 1,031 | 1,058 | 0.001 |
| Female sex | 0,708 | 0,512 | 0,981 | 0.038 |
| Diabetes | 1,286 | 0,966 | 1,713 | 0.085 |
| Creatinine, mg/dl | 1,235 | 1,117 | 1,366 | 0.001 |
| Coronary calcium volume, mm3 | 1,082 | 1,033 | 1,133 | 0.001 |
| Lung interstitial involvement, n/N | 1,200 | 1,020 | 1,412 | 0.028 |
Cox regression models: top to bottom univariate Cox regression, multivariate Cox regression with quantitative coronary calcifications (volume mm3), multivariate cox regression using coronary calcifications categorized according to cut-offs of 100 and 400 mm3. In the last model, calcium volume is expressed as an ordinal variable for every 100 mm3 of calcium volume (including only patients with values between 0 and 1000 mm3)