Table 4.

Combined IL-6 and CRP and Incident MMD (estimates with 95% confidence intervals)

	MMD Event Rate/100 PY*				Relative Risk of MMD†
					IL-6 ≤2.5 pg/mL		IL-6 >2.5 pg/mL
	CRP ≤3.0 mg/L, IL-6 ≤2.5 pg/mL	CRP >3.0 mg/L, IL-6 ≤2.5 pg/mL	CRP <3.0 mg/L, IL-6 >2.5 pg/mL	CRP >3.0 mg/L, IL-6 >2.5 pg/mL	CRP >3.0 vs. CRP ≤3.0	p	CRP >3.0 vs. CRP ≤3.0	p
					Hazard Ratio		Hazard Ratio
Overall	18.0 (14.4–22.4)	21.8 (17.0–28.0)	15.0 (10.9–20.7)	25.6 (21.6–30.2)	1.19 (0.85–1.66)	.311	1.62 (1.12–2.33)	.010

Note: IL-6 = interleukine-6; CRP = C-reactive protein; MMD = major mobility disability.

*Estimated from a Poisson regression model stratified by study.

^†Estimated from Cox proportional hazards regression model stratified by study with CRP category, IL-6 category, and CRP × IL-6 interaction as predictors.