Table 2.

Associations Between Traits Previously Correlated With Circulating IL-6, With Both Measured log(IL-6) and the DNAm IL-6 Score in Generation Scotland

	Log(IL-6) (n = 417)				DNAm IL-6 Score—Subset With Measured IL-6 (n = 417)				DNAm IL-6 Score—Full Data set (N = 7028)
	β	SE	p	p FDR	β	SE	p	p FDR	β	SE	p	p FDR
BMI	0.21	0.04	1.2 × 10 −6	3.2 × 10 −6	0.15	0.08	.073	.12	0.088	0.02	8.3 × 10 −7	3.0 × 10 −6
SIMD	−0.051	0.05	.28	.38	0.04	0.08	.60	.62	−0.24	0.02	<2 × 10 −16	<2 × 10 −16
Alcohol	0.035	0.05	.51	.59	0.11	0.08	.20	.27	0.079	0.02	1.0 × 10 −5	2.6 × 10 −5
Smoking	0.15	0.09	.11	.19	0.82	0.15	5.5 × 10 −8	2.4 × 10 −7	1.20	0.04	<2 × 10 −16	<2 × 10 −16

Note: BMI = body mass index; SIMD = Scottish Index of Multiple Deprivation. Log odds are presented for smoking. Significant associations are highlighted in bold.