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. 2021 Mar 10;28(10-11):659–675. doi: 10.1038/s41434-021-00250-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Analysis of blood levels of molecules relevant to nerve pathology in 10-month-old AAV9-Mpz.GJB1 treated (GJB1) Gjb1-null mice compared to AAV9-Mpz.Egfp (mock) treated littermates, as well as age-matched WT and untreated Gjb1-null mice: A Neurofilament light (NF-L) plasma concentration is increased in Gjb1-null (n = 5) compared to WT (n = 8) mice and shows significant amelioration in post-onset treated mice compared to mock treated mice (n = 6 per group). B: Neural cell adhesion molecule-1 (NCAM-1) serum levels were similarly increased in untreated Gjb1-null (n = 4) compared to WT (n = 3) mice and showed significant improvement in treated compared to mock-treated group (n = 7 per group) (one-way ANOVA with Bonferroni post-test; *P < 0.05, **P < 0.01 and ***P < 0.001).