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. 2021 Nov 3;599(7885):471–476. doi: 10.1038/s41586-021-04082-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a, Scheme of macrophage conditioning with activated B cells followed by polarization with IL-10 (M-IL-10 and B cells-M-IL-10) and co-culture with CD8⁺ T cells stimulated with anti-CD3 and anti-CD28 for 72 h in the presence or absence of IL-10 blocking antibodies (Abs). b, c, Representative flow cytometry profiles of CD8⁺ T cells stained for granzyme B and CD25 (b), and quantification of the granzyme B⁺ CD25⁺ cells in CD8⁺ gates (upper graph) or the concentration of IFNγ and TNF in the culture supernatants (lower graphs) (n = 3 (M-IL-10 + CD8⁺ +/- IL-10 blocking Abs) or 6 (B-M-IL-10 + CD8⁺ +/- IL-10 blocking Abs)) (c) are shown. ns: not significant, *P < 0.05, **P < 0.01, ***P < 0.001 (one-way ANOVA). Bars represent mean ±SEM. Circles on graphs indicate an individual sample. n indicates technical replicates. Data are representative of two experiments. Exact P values are in Source Data.

Source data