Table 2.
The EMPEROR-Reduced risk model for all-cause mortality
| Hazard ratio (95% CI) | χ 2 statistic | Coefficient (SE)a | P-value | |
|---|---|---|---|---|
| Log NT-proBNP (pg/mL)b | 1.61 (1.45–1.79) | 79.0 | 0.48 (0.05) | <0.0001 |
| Log hs-cTnT (ng/L)b | 1.58 (1.40–1.79) | 51.0 | 0.46 (0.06) | <0.0001 |
| NYHA Class III/IV (vs. Class II) | 1.40 (1.17–1.68) | 12.9 | 0.34 (0.09) | 0.0003 |
| Ischaemic (vs. non-ischaemic) heart failure | 1.38 (1.16–1.65) | 13.0 | 0.32 (0.09) | 0.0003 |
An estimate of each individual’s 2-year risk can be calculated as follows: 1 − [0.9991^exp(0.48 × log NT-proBNP + 0.46 × log hs-cTnT + 0.34 × NYHA + 0.32 × ischaemic)], where ‘NYHA’ is an indicator variable for whether the patient’s NYHA class is III or IV and ‘ischaemic’ is an indicator variable for whether their heart failure was of ischaemic aetiology.
CI, confidence interval; hs-cTnT, high-sensitivity cardiac troponin T; NT-proBNP, N-terminal pro B-type natriuretic peptide; NYHA, New York Heart Association; SE, standard error.
Coefficient (SE) is the log hazard ratio and its standard error.
Per 1 unit higher on the log scale, equal to 2.7-fold levels of either NT-proBNP or hs-cTnT levels.