Table 2.

Linear Regression β-Coefficients and 95% Confidence Intervals for the Association Between Metabolic Syndrome and Composite Cognitive Domain

Composite Domains	Model 1*		Model 2†		Model 3‡
	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p
G-score	−0.12 (−0.19, −0.06)	<.001	−0.12 (−0.20, −0.04)	.003	−0.13 (−0.21, −0.04)	.003
Episodic memory	−0.10 (−0.18, −0.01)	.027	−0.08 (−0.19, 0.02)	.114	−0.08 (−0.18, 0.03)	.149
Attention/perceptual speed	−0.14 (−0.23, −0.05)	.003	−0.13 (−0.24, −0.02)	.024	−0.14 (−0.25, −0.02)	.016
Executive function	−0.09 (−0.19, −0.004)	.041	−0.12 (−0.23, −0.004)	.041	−0.12 (−0.23, −0.01)	.037
Verbal fluency	−0.21 (−0.30, −0.11)	<.001	−0.18 (−0.29, −0.06)	.002	−0.19 (−0.30, −0.08)	.002
Visuospatial abilities	−0.07 (−0.19, 0.04)	.223	−0.11 (−0.24, 0.03)	.130	−0.10 (−0.24, 0.04)	.142

Notes: APOE-ɛ4 = apolipoprotein E gene-ɛ4 allele; CI = confidence intervals; G-score = composite score for global cognition; TIA = transient ischemic attack. In all models, the reference group included participants without metabolic syndrome.

*Model 1: adjusted for sex and education.

^†Model 2: adjusted for sex, education, physical activity, smoking, alcohol risk consumption, heart disease, and stroke/TIA.

^‡Model 3: adjusted for sex, education, physical activity, smoking, alcohol risk consumption, heart disease, stroke/TIA, and APOE-ɛ4.