Figure 2.

Modelled Kaplan–Meier curves.

Modelled RFS curves of pembrolizumab (also used for nivolumab, ICI), dabrafenib-trametinib (TT), and routine surveillance were based on corresponding trials, i.e. KEYNOTE-054 and COMBI-AD, respectively. In the absence of OS data, RFS data were extrapolated (lifetime horizon) and corrected for background mortality. As the RFS data from the COMBI-AD trial were the most mature, these OS data were used for all adjuvant systemic treatment regimens (dabrafenib-trametinib, as well as pembrolizumab and nivolumab) versus placebo (as a proxy for routine surveillance). ICI, immune checkpoint inhibitor (nivolumab/pembrolizumab); OS, overall survival; RFS, recurrence-free survival; TT, targeted therapy (dabrafenib-trametinib).