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. 2021 Nov 4;3:764079. doi: 10.3389/fdgth.2021.764079

Table 1.

Characteristics of the included studies.

Author(s), year, country (References) Study type Theoretical model Duration of intervention Sample mental health characteristics Target population Baseline sample size Primary mental health outcome Engagement metric(s)
Unguided interventions (17 studies)
Andersson et al., 2005, Sweden (33) RCT Internet-administered self-help (CBT) 5 modules / 8 weeks Mild to moderate symptoms of depression; based on self-report. Adults
Mage = 36.4 (11.5)
78% female
57 Depression Modules completed (+)
Berger et al., 2011, Switzerland (34) RCT Internet-based self-help (CBT) 5 lessons / 10 weeks Fulfill diagnostic criteria for social anxiety disorder. Adults
Mage = 37.2 (11.2)
53.1% female
81 Anxiety (social phobia) Lessons completed (+)
Time spent (+)
No. of clicks (+)
No. of diary entries (+)
Berger et al., 2017, Switzerland (35) RCT Velibra (CBT) 6 modules / 9 weeks Fulfill diagnostic criteria for anxiety-related disorders. Adults
Mage = 42.0 (12.1)
70.5% female
70 Psychological distress Modules completed (ns)
Time spent (ns)
Bolier et al., 2013, Netherlands (36) RCT Psyfit (Positive psychology) 6 modules / 8 weeks Mild to moderate symptoms of depression; based on self-report. Adults
Mage = 43.5 (11.7)
79.7% female
143 Psychological distress Lessons completed (+)
Bruehlman-Senecal et al., 2020, USA (37) RCT Nod (Positive psychology, Mindfulness-based self-compassion, CBT) No module information / 4 weeks No mental health-related inclusion criteria. 1st year college students.
Mage = 18.7 (0.33)
51% female
100 Loneliness App pages visited (ns)
Social challenges completed (+)
Reflections accessed (ns)
Calear et al., 2013; Australia (38) Secondary analysis MoodGym (CBT) 5 modules / 9 weeks No mental health-related inclusion criteria. School children
Mage = 14.56 (0.68)
63.1% female
530 Anxiety (general)
Depression
Exercises completed (ns for both outcomes)
Casey et al., 2017; Australia (39) RCT Improving the Odds (CBT) 6 modules / 6 weeks Fulfill diagnostic criteria for gambling disorder. Adults
Mage = 14.56 (0.68)
79.7% female
60 Gambling cognitions Sessions completed (+)
Forand et al., 2017, Netherlands (40) Secondary analysis Color Your Life (CBT) 9 sessions / 9 weeks Mild to moderate symptoms of depression; based on self-report. Adults
Mage = 44.7 (11.3)
200 Depression Modules completed (+)
Heckendorf et al., 2019, Germany (41) RCT GET.ON Gratitude (Gratitude) 5 modules / 5 weeks Elevated levels of repetitive negative thinking; based on self-report. Adults
Mage = 42.3 (10.6)
54.5% female
132 Repetitive negative thinking Activities completed (+)
Hensel et al., 2019, Canada (42) RCT Big White Wall (BWW) No module information / 13 weeks (3 months) Attending outpatient mental health programs. No diagnostic information. Adults
Mage = 41.5 (13.4)
73% female
542 Psychological recovery No. of logins (ns)
Krieger et al., 2019, Switzerland (43) RCT Mindfulness-Based Compassionate Living (MBCL) 7 modules / 8 weeks Elevated levels of self-criticism; based on self-report. Adults
Mage = 38.0 (12.0)
84.7% female
59 Self-compassion Modules completed (+)
Time spent in program (ns)
Levin et al., 2016, USA (44) RCT Acceptance and Commitment Training on College Life (ACT-CL) 2 modules / 3 weeks No mental health information. Young adults (college students)
Mage = 21.6 (5.48)
76.9% female
110 Psychological distress Sessions completed (ns)
No. of logins (ns)
Response to exercises (ns)
Luo et al., 2021, China (45) RCT eBody Project 6 modules / 6 weeks Body dissatisfaction; based on self-report Youths and young adults
M = 17.36 (1.37)
100% female
191 Body dissatisfaction Sessions completed (ns)
Twomey et al., 2014, Ireland (46) RCT MoodGym (CBT) 6 modules / 4 weeks Self-reported symptoms of stress, anxiety, or depression Adults
Mage = 37.3 (10.9)
89.3% female
80 Psychological distress Sessions completed (ns)
Wilson et al., 2018, USA (47) RCT Goalistics Chronic Pain Management Program (CBT) 2 h per week / 8 weeks (No. modules not stated) Patients with chronic non-cancer pain and receiving treatment for opioid use Adults
Mage = 45.5 (12.4)
48.4% female
31 Pain self-efficacy Activities completed (+)
Wilson et al., 2018, USA (48) RCT Think Clearly About Depression (CBT) 14 modules / 8 weeks Self-reported symptoms of depression of moderate severity Adults
Mage = 45.7 (12.8)
91% female
22 Depression Activities completed (ns)
Zeng et al., 2020, China (49) Secondary analysis Run4Love (CBT) 65 activities / 12 weeks Individuals with HIV with self-reported elevated symptoms of depression Adults
Mage = 28.0 (5.8)
5.3% female
150 Depression Item completion rate (+)
Frequency of items completed (+)
Time spent (ns)
Guided interventions (14 studies)
Ben-Zeev et al., 2018, USA (50) RCT FOCUS (CBT) 12 weeks Fulfill diagnostic criteria for schizophrenia-related, bipolar, or depressive disorder. Adults
Mage = 49.0 (9.8)
42% female
82 Psychological recovery Weeks completed (+)
Berger et al., 2014; Switzerland (51) RCT Internet-Based Self-Help (CBT) 8 sessions / 8 weeks Fulfill diagnostic criteria for anxiety-related disorders. Adults
Mage = 34.7 (11.3)
56.8% female
88 Anxiety (general) Sessions completed (+)
Cillessen et al., 2020, Netherlands (52) Secondary analysis Mindfulness-based cognitive therapy (MCBT) 9 sessions / 9 weeks Cancer patients with mild psychological distress; based on self-report. Adults
Mage = 52.0 (10.2)
125 Psychological Distress Exercises completed (+)
Emails sent (ns)
Mean time logged in (ns)
Total time logged in (ns)
No. of logins (ns)
El Alaoui et al., 2013, Sweden (53) Secondary analysis ICBT 10 modules / 10 weeks Fulfill diagnostic criteria for panic disorder. Adults
Mage = 33.8 (9.7)
50 Anxiety (panic disorder) Modules completed (ns)
Hedman et al., 2015, Sweden (54) Secondary analysis ICBT (CBT) 12 modules / 12 weeks Fulfill diagnostic criteria for hypochondriasis. Adults
Mage = 41.7 (13.6)
85% female
79 Anxiety: health-related Modules completed (+)
Hedman et al., 2013, Sweden (55) Secondary analysis ICBT (CBT) 12 modules / 12 weeks Fulfill diagnostic criteria for hypochondriasis. Adults
Mage = 39 (9.7)
74% female
81 Anxiety: health-related Modules completed (+)
Lenhard et al., 2017, Sweden (56) RCT BiP for OCD (CBT) 12 chapters / 12 weeks Fulfill diagnostic criteria for OCD. Youth
Mage = 15.0 (1.66)
41% female
33 OCD severity Chapters completed (ns)
Lundgren et al., 2016, Sweden (57) RCT ICBT (CBT) 7 modules / 9 weeks Mild to moderate symptoms of depression; based on self-report Adults
Mage = 63.6 (13.9)
60% female
25 Depression Modules completed (ns)
No. of logins (+)
Moberg et al., 2019, USA (58) RCT Pacifica (CBT, Mindfulness) 35 lesson-activity pairs / 5 weeks Self-reported, mild to moderate symptoms of depression or anxiety. Adults
Mage = 30.2 (10.9)
75% female
253 Depression
Anxiety
No. logins (ns for both)
Activities completed (ns for both)
Norlund et al., 2018, Sweden (59) RCT ICBT 10 modules / 14 weeks Patients with myocardial infarction with mild symptoms of depression or anxiety. Adults
Mage = 58.4 (9.0)
37.6% female
117 Psychological distress Homework assignments completed (ns)
Schlosser et al., 2018, USA (60) RCT PRIME (personalized real-time intervention for motivational enhancement; CBT) NA / 12 weeks (at least 1 login per week) Meet criteria for schizophrenia- related disorders Adults
Mage = 24.3 (2.6)
40% female
22 Motivation in schizophrenia No. coach interactions (ns)
No. peer interactions (ns)
Goals completed (ns)
Spence et al., 2017, Australia (61) RCT BRAVE-Online (CBT) 10 sessions / 10 weeks Meet criteria for social anxiety disorder. Children and youth
Mage = 11.0 (2.57)
62.1% female
95 SAD diagnostic severity Sessions completed (ns)
Stjerneklar et al., 2019, Denmark (20) Secondary analysis ChilledOut Online (CBT) 8 modules / 14 weeks Meet criteria for an anxiety disorder. Youth
Mage = 15.2 (1.33)
78% female
64 Anxiety Modules completed (ns)
Todd et al., 2014, UK (62) RCT Living With Bipolar (LWB; CBT) 15 modules / 12 weeks Self-reported symptoms of bipolar disorder. Adults
Mage = 42.0 (10.4)
74% female
59 Quality of life (bipolar disorder) Modules completed (ns)
Guided and unguided interventions (4 studies)
Fuhr et al., 2018, Germany (63) Secondary analysis Deprexis (CBT) 10 modules / 12 weeks Mild to moderate symptoms of depression; based on self-report. Adults
Mage = 42.8 (11.0)
68.8% female
485 Depression Sessions completed (+)
Time spent (+)
Levin et al., 2021, USA (64) RCT Online Acceptance Commitment Therapy (ACT) 12 sessions / 6 weeks Psychological distress; based on self-report. Young adults (college students) with self-reported
Mage = 22.3 (5.08)
72.4% female
136 Psychological distress Sessions completed (ns)
Mira et al., 2017, Spain (65) RCT Sonreír es Divertido (Cognitive therapy, positive psychology) 8 modules / 12 weeks Mild to moderate symptoms of depression; based on self-report Adults
Mage = 35.2 (9.7)
65% female
80 Depression Modules completed (+)
Oromendia et al., 2016, Spain (66) RCT Free from Anxiety (CBT) 8 modules / 8 weeks Meet criteria for panic disorder. Adults
Mage = 39.4 (8.5)
73.1% female
52 Anxiety (panic disorder) Modules completed (+)

+Greater engagement associated with post-intervention mental health improvements.

ns, no association between engagement measure and post-intervention symptoms.