REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
SARS-CoV-2 (nucleocapsid)	SinoBiological	40143-R001; RRID:AB_2827974
mucin5AC (clone 45M1)	ThermoFisher	MS-145-P; RRID:AB_62731
acetylated tubulin	Sigma	T6793; RRID:AB_477585
Goat anti-rabbit AF488	ThermoFisher	A11008; RRID:AB_143165
Goat anti-mouse A647	ThermoFisher	A-21240; RRID:AB_141658
Goat anti-mouse AF568	ThermoFisher	A-21144; RRID:AB_2535780
Bacterial and virus strains
HCoV-229E	Volker Thiel (Universität Bern)	NA
SARS-CoV-2	Christian Drosten (Charité, Berlin) through the European Virus Archive – Global (EVAg)	SARS-CoV-2/München-1.2/2020/984,p3
SARS-CoV-2 (ALI experiment)	GeneBank	SARS-CoV-2/01/human/2020/SWE
		GeneBank accession no. MT093571.1
Chemicals, peptides, and recombinant proteins
Hoechst33342	ThermoFisher	62249
Fluvastatin	Sigma	SML0038
Simvastatin	Sigma	S6196
Atorvastatin	Sigma	PZ0001
Lovastatin	Sigma	M2147
Pravastatin	biomol	Cay-10010342
Rosuvastatin	Sigma	SML1264
Chloroquine	Sigma	C6628
MTT reagent (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide	invitrogen	M6494
Critical commercial assays
NucleoSpin RNA kit	Macherey-Nagel	740955.250
QIAamp Viral RNA Mini Kit	Qiagen	52906
SuperScript™ III One-Step RT-PCR System with Platinum™ Taq DNA Polymerase	invitrogen	12574026
PrimeScript™ RT Master Mix	Takara	RR036A
TB Green® Premix Ex Taq™	Takara	RR82LR
qPCRBIO Probe 1-Step Go master mix	PCR Biosystems	PB25.41-03
Deposited data
mass spectrometry proteomics data	ProteomeXchange	ProteomeXchange: PXD023422
Experimental models: Cell lines
HEK293T	ATCC	CRL-3612
Huh7.5 FLuc	kindly provided by Charles M. Rice (Rockefeller Institute, NY, US)	NA
Calu-3	kindly provided by Stefan Pöhlmann (German Primate Center, Göttingen, Germany).	ATCC-HTB-55
Vero	ATCC	CCL-81
Vero E6	ATCC	CRL-1586
Experimental models: Organisms/strains
Primary human bronchial epithelial cells	Patient derived (University hospital of Umeå, Sweden)	NA
Oligonucleotides
RFC2 primer set: CCAGCAAGCCTTGAGGAGAAC, GGCTCGATGATCTTATCCGAAG	Microsynth	NA
HMGA2 primer set: ACCCAGGGGAAGACCCAAA, CCTCTTGGCCGTTTTTCTCCA	Microsynth	NA
NCL primer set: GAACCGACTACGGCTTTCAAT, AGCAAAAACATCGCTGATACCA	Microsynth	NA
ß-actin primer set: CAC CAT TGG CAA TGA GCG GTT C, AGG TCT TTG CGG ATG TCC ACG T	Microsynth	NA
SARS-CoV-2 primer and probe: fv: GTGARATGGTCATGTGTGGCGG, rv: CARATGTTAAASACACTATTAGCATA, probe: FAM-CAGGTGGAACCTCATCAGGAGATGC-BBQ	TIB MOLBIOL	NA
SARS-CoV-2 primer and probe (ALI experiment): fv: GTCATGTGTGGCGGTTCACT, rv: CAACACTATTAGCATAAGCAGTTG T, probe: CAGGTGGAACCTCATCAGGAGATGC	Eurofins genomics	NA
Software and algorithms
Peaks X+	Bioinformatics Solutions	https://www.bioinfor.com/peaks-studio-x-plus/
MaxQuant (1.6.17.0)	MaxQuant	https://www.maxquant.org/
R (4.0.2)	R Foundation	https://www.R-project.org/
STRING	STRING Consortium	https://string-db.org/
Cytoscape 3.8.2	Cytoscape Consortium	https://cytoscape.org/
BioRender	BioRender	https://biorender.com/
GraphPad Prism8	GraphPad	https://www.graphpad.com/scientific-software/prism/