FIGURE 2.

Factors influencing the development of AD–the most common type of dementia. Genetic and environmental factors are mentioned as the main risk factors for developing AD. Apolipoproteins E lead to irregular amyloid β aggregation. Mutations of genes such as HLA-DRB5-DRB1, INPP5D, MEFLC, PTK2B, CELF1, NME8, CASS4 and FERMT2 may induce the dysfunctions of brain physiological processes. Other factors such as hypertension, obesity, diabetes, blood circulation disorders, oxidative stress and inflammation, also influence AD progression. People over the age of 65 years, especially postmenopausal women, are more predisposed to AD development.