Figure 7.

Peripheral serum concentrations (median and interquartile range) of adrenarchal C19 steroids in girls with and without PreAd. Samples obtained during clinic hours; subjects predominantly non-Hispanic White; PreAd group had Tanner pubic hair stage 2. Steroids all assayed by LCMSMS. All the differences between the steroids in PreAd and the age-matched control girls were statistically significant except for androstenedione. Note that each panel shows steroids on a different scale. Conversion multiplier for androstenediol sulfate (5AdioS) from µg/dL to µmol/L: 0.0270. Conversion multipliers from ng/dL to nmol/L for unconjugated steroids not listed in Table 1: 11β-hydroxyandrostenedione (11OHA) 0.0331; 11-ketotestosterone (11KT) 0.0331; 1-ketoandrostenedione (11KA) 0.0331; 11β-hydroxytestosterone (11OHT) 0.0328. For comparison, normal median (interquartile range) values for the 11-oxyandrogens in reproductive-age women are 11-hydroxyandrostenedione 117 (86-151), 11-ketoandrostenedione 15 (12-21), 11-hydroxytestosterone 11 (7-16), and 11-ketotestosterone 21 (16-32) ng/dL (99). The 11-oxyandrogen values of men this age are minimally higher (99).

Graphed from data of Rege et al (54).