Table 1.
Top 30 most differentially expressed genes by the METH and EcoHIV interaction in SVZ-derived NPCs. All of the top 30 genes had the FDR<0.05 which means that the selected genes have <5% chance of being significant based on chance-alone
| No | Entrez Gene ID | Gene name | Description | DESeq2 P:Substance by Virus Interaction | log2 Fold Change: ME vs. MC | log2 Fold Change: ME vs. SE | Targets of FOXOs | Target of FOXO3 |
|---|---|---|---|---|---|---|---|---|
| 1 | 219140 | Spata13 | spermatogenesis associated 13 | 3.44E-04 | -0.41 | -0.64 | x | x |
| 2 | 14371 | Fzd9 | frizzled class receptor 9 | 3.44E-04 | 0.52 | 0.69 | x | |
| 3 | 76453 | Prss23 | protease, serine 23 | 3.99E-04 | -0.23 | -0.81 | x | |
| 4 | 54710 | Hs3st3b1 | heparan sulfate (glucasamine) 3-O-sulfotransferase 3B1 | 3.03E-03 | 0.50 | -0.48 | x | x |
| 5 | 53325 | Banp | BTG3 associated nuclear protein | 5.68E-03 | 0.26 | 0.42 | x | x |
| 6 | 244867 | Arhgap20 | Rho GTPase activating protein 20 | 5.68E-03 | -0.79 | -0.27 | x | |
| 7 | 76960 | Bcas1 | breast carcinoma amplified sequence 1 | 6.46E-03 | 1.25 | 0.85 | x | |
| 8 | 13052 | Cxadr | coxsackie virus and adenovirus receptor | 6.46E-03 | -0.35 | -0.77 | x | x |
| 9 | 69908 | Rab3b | RAB3B, member RAS oncogene family | 6.46E-03 | -0.60 | -0.62 | x | x |
| 10 | 23965 | Tenm3 | teneurin transmembrane protein 3 | 6.46E-03 | -0.34 | -0.46 | ||
| 11 | 11541 | Adora2b | adenosine A2b receptor | 8.69E-03 | 0.11 | 1.67 | x | |
| 12 | 12014 | Bach2 | BTB and CNC homology 2, basic leucine zipper transcription factor 2 | 8.69E-03 | -0.16 | -0.66 | x | x |
| 13 | 20284 | Scrg1 | scrapie responsive gene 1 | 9.70E-03 | 0.62 | 0.43 | x | x |
| 14 | 17536 | Meis2 | Meis homeobox 2 | 1.21E-02 | -0.12 | -0.28 | x | |
| 15 | 72693 | Zcchc12 | zinc finger, CCHC domain containing 12 | 1.49E-02 | -0.08 | -0.54 | x | |
| 16 | 56847 | Aldh1a3 | aldehyde dehydrogenase family 1, subfamily A3 | 1.49E-02 | 0.00 | -0.71 | x | |
| 17 | 15205 | Hes1 | hes family bHLH transcription factor 1 | 2.58E-02 | 0.11 | 0.64 | x | x |
| 18 | 71718 | Telo2 | telomere maintenance 2 | 2.81E-02 | 0.62 | 0.38 | x | |
| 19 | 140571 | Plxnb3 | plexin B3 | 3.21E-02 | 0.95 | 0.39 | x | |
| 20 | 240322 | Adamts19 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19 | 3.21E-02 | -0.78 | -0.98 | x | |
| 21 | 226255 | Atrnl1 | attractin like 1 | 3.21E-02 | -0.31 | -0.46 | x | |
| 22 | 73230 | Bmper | BMP-binding endothelial regulator | 3.21E-02 | -0.66 | -0.42 | x | x |
| 23 | 14164 | Fgfh1 | fibroblast growth factor 1 | 3.21E-02 | 0.36 | 0.84 | x | |
| 24 | 14432 | Gap43 | growth associated protein 43 | 3.21E-02 | -0.15 | -0.86 | x | |
| 25 | 52857 | Gramd1a | GRAM domain containing 1A | 3.21E-02 | 0.52 | 0.41 | x | |
| 26 | 14812 | Grin2b | glutamate receptor, ionotropic, NMDA2B (epsilon 2) | 4.04E-02 | -1.78 | -0.96 | x | x |
| 27 | 18223 | Numbl | numblike | 4.04E-02 | -0.19 | 0.42 | x | |
| 28 | 18451 | P4ha1 | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase)m alpha 1 polypeptide | 4.10E-02 | 0.10 | 0.41 | x | x |
| 29 | 107065 | Lrrtm2 | leucine rich repeat transmembrane neuronal 2 | 4.10E-02 | -0.05 | -0.67 | ||
| 30 | 99633 | Adgrl2 | adhesion G protein-coupled receptor L2 | 4.25E-02 | -0.42 | -0.34 |