Fig. 2.

TEAD2, TEAD4 and ZIC3 can promote reprogramming of human UCs into iPSCs. a Construction map of Episomal vectors of TEAD2, TEAD4 and ZIC3: pCEP4-TEAD2, pCEP4-TEAD4, pCEP4-ZIC3. b Reprogramming protocol: add 5i to RM medium during induction period, and add 5i + PD to mTeSR1 medium during proliferation period. c The morphological changes of induced cells in different time points during the reprogramming process. d AP staining of each group iPSCs induced from UCs. e The number of AP+ clone number of each group of UCs. Data represented as mean ± SEM from three independent assays. *P < 0.05, **P < 0.01, ***P < 0.001, unpaired two tailed student-t-test