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. 2021 Aug 26;17(6):2223–2234. doi: 10.1007/s12015-021-10220-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Characteristics of the reprogrammed UiPSCs-TEAD2, UiPSCs-TEAD4 and UiPSCs-ZIC3 cell lines. a The morphology of UiPSCs-TEAD2, UiPSCs-TEAD4 and UiPSCs-ZIC3 clones are similar to H1 and UiPSCs (bar: 200 μm). b Detection of exogenous reprogramming factor integration by PCR analysis using genomic DNA in the UiPSCs clones. c immunofluorescence images of the pluripotency markers (OCT4, SOX2 SSEA4 and TRA-1-60) in UiPSCs-TEAD2, UiPSCs-TEAD4 and UiPSCs-ZIC3 cells (bar: 50 μm). d The R² correlation coefficient matrix of all versus all RNA-seq datasets as indicated. e The expression level for select pluripotent genes from RNA-seq data. Data represented as mean ± SEM from two replicates. f Teratoma assay of UiPSCs-TEAD2, UiPSCs-TEAD4, UiPSCs-ZIC3 and control UiPSCs. H&E staining was performed after 4 weeks subcutaneous injection, each image presents histology consistent with endoderm, mesoderm or ectoderm. (bar: 90 μm)