FIGURE 10.

Changes in oxytocin-induced uterine peristalsis and Ca²⁺ oscillations in neonatal adenomyotic mice. (A) Time courses of uterine peristalsis in response to accumulative oxytocin (OT) stimulation in postnatal day (PND) 14 mice after treatment with the vehicle for tamoxifen (Ctrl) [A(i)] and the same age mice after treatment with tamoxifen (Adeno) [A(ii)]. The concentrations of OT are labeled above the traces. (B) Uterine peristalsis frequency changes caused by OT in uterine slices from Ctrl (O; blue line) and Adeno (Δ; red line) mice at PND14. (C) Changes in the AUC of uterine peristalsis by OT in uterine slices from Ctrl (O; blue line) and Adeno (Δ; red line) mice at PND14. (D) Time courses of Ca²⁺ oscillations in response to accumulative OT stimulation in Ctrl [D(i)] and Adeno mice [D(ii)] at PND14. The concentrations of OT are labeled above the traces. (E) Ca²⁺ oscillation frequency changes caused by OT in uterine slices from Ctrl (O; blue line) and Adeno (Δ; red line) mice at PND14. (F) OT-induced changes in the AUC of Ca²⁺ oscillations in uterine slices from Ctrl (O; blue line) and Adeno (Δ; red line) mice at PND14. N = 5 Ctrl mice (10 slices) and 5 Adeno mice (10 slices) from for panels (B,C,E,F). ****P < 0.0001 by a two-way ANOVA.