Fig. 3.

Interaction sites of dystrophin isoform Dp427-M and overview of the dystrophin-glycoprotein complex at the sarcolemma of skeletal muscle fibres. Abbreviations used: ABD, actin-binding domain; CT, carboxy-terminus; CR, cysteine-rich domain; DG, dystroglycan; DYB, dystrobrevin; Dp427-M, muscle-specific dystrophin isoform of 427 kDa; H, proline-rich hinge region; nNOS, neuronal isoform of nitric oxide synthase; NT, amino-terminus; SG, sarcoglycan; SLR, spectrin-like rod domain; SSPN, sarcospan; SYN, syntrophin; WW, conserved region with signature tryptophan residues