FIGURE 1.

Rett syndrome (RTT)‐like neurological phenotypes are observed in male and female Mecp2 R133C mice. (A) Attenuated weight across all ages (5–11 week‐old males [n = 11–28 per genotype], and 5–25 week‐old females, n = 14–25 per genotype)). (B–F) Mecp2 R133C mice exhibited hindlimb clasping (representative images shown, (B), attenuated acoustic startle response to a 120 dB stimulus (C), decreased latency to fall on an accelerated rotarod (D), normal spontaneous locomotor activity in the open field task (E), and increased time spent in the open arms of an elevated zero maze (F). n = 15–33 per genotype in males, n = 18–32 per genotype in females. Mixed‐effects analysis with Sidak's post‐hoc test, or unpaired t‐test. *within‐genotype comparison. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. WT = filled or patterned black bars or closed or open black circles. Mecp2 R133C = filled or patterned purple bars or closed or open purple triangles. Male = filled, closed. Female = patterned, open