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. 2021 May 28;21(1):e12752. doi: 10.1111/gbb.12752

FIGURE 5.

FIGURE 5

Wild‐type (WT) MECP2 corrects abnormal behaviors observed in Mecp2 R133C/y mice. (A–E) Weight deficit (n = 11–32 per genotype) (A), hindlimb clasping (n = 16–31 per genotype) (B), attenuated acoustic startle response (14–29 per genotype) (C), lack of social preference (n = 15–30 per genotype) (D), and increased apneas (n = 16–32 per genotype) (E) in Mecp2 R133C/y mice were normalized in MECP2 Tg1/o ; Mecp2 R133C/y mice. Male MECP2 Tg1/o mice also exhibited normal behavior in these assays when compared to WT littermates. Representative hindlimb clasping and apnea traces are shown. Mixed‐effects analysis, or one‐ or two‐way analysis of variance (ANOVA) with Tukey's or t‐test post‐hoc. ns (not significant), **p < 0.01, ***p < 0.001, ****p < 0.0001. WT = filled black bars or circles. MECP2 Tg1/o  = filled blue bars or squares. Mecp2 R133C/y  = filled purple bars or triangles. MECP2 Tg1/o ; Mecp2 R133C/y  = filled green bars or diamonds