FIGURE 7.

Additional wild‐type (WT) MECP2 normalizes a subset of phenotypes in Mecp2 ^R133C/+ mice. (A–E) MECP2 ^Tg1/o ; Mecp2 ^R133C/+ mice exhibited similar weight (n = 14–26 per genotype) (A), hindlimb clasping behavior (n = 26–40 per genotype) (B), acoustic startle response (n = 18–22 per genotype) (C), social preference (n = 25–31 per genotype) (D), and number of apneas (n = 25–33 per genotype) (E) as WT littermates, illustrating a reversal of abnormal phenotypes observed in Mecp2 ^R133C/+ mice. Representative hindlimb clasping and apnea traces are shown. Mixed‐effects analysis, or one‐ or two‐way analysis of variance (ANOVA) with Tukey's or t‐test post‐hoc. ns (not significant), *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. WT = patterned black bars or open circles. MECP2 ^Tg1/o  = patterned blue bars or open squares. Mecp2 ^R133C/+  = patterned purple bars or open triangles. MECP2 ^Tg1/o ; Mecp2 ^R133C/+  = patterned green bars or open diamonds