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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Semin Cancer Biol. 2021 May 18;76:110–119. doi: 10.1016/j.semcancer.2021.05.016

Figure 2: Modes of NRF2 inhibition decrease cancer cell viability.

Figure 2:

Prolonged or constitutive NRF2 activation increases cancer progression, but NRF2 inhibition via 1) E3-ligase dependent proteasomal degradation, 2) DNA binding disruption, and 3) translational or epigenetic regulation can decrease overall NRF2 expression and activity to decrease cancer cell viability.