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No gross changes, such as photothermal injury, were observed after photodynamic therapy during the initial period. A week after photothermal therapy, tumor mass decreased with peri-tumoral mucosal edema. Two weeks after PDT, superficial necrosis was observed in the tumor. Small-sized tumors in two animals in Group A-1 that did not cross the midline of the vocal cord healed completely with restoration of vocal cord edema 3 weeks post PDT
