Fig. 2.

Doubling time and lifespan of natural product-treated yeast with outgrowth kinetics and Kaplan–Meier curves for lifespan decreasing treatments. A Relationship between doubling time (minutes/cell division) and median RLS for natural product-treated yeast (standard major axis regression, adjusted R-squared = 0.06, p-value = 0.24). B Green tea extract (GTE) decreases RLS (Wilcoxon rank-sum test, Bonferroni corrected (*p < 0.05, **p < 0.01, ***p < 0.001)). C Berberine is a general inhibitor of yeast growth (Welch’s T-test, Bonferroni corrected). D Berberine RLS dose response (Wilcoxon rank-sum test, Bonferroni corrected). For number of cells or cultures tested and p-values, see Tables 5 and 6