Table 5.
Median RLS (95% confidence intervals), number of cells dissected (n), percent change, and p-value (Wilcoxon rank-sum test, Bonferroni-corrected p-value for multiple testing and uncorrected p-value in parentheses) of natural product compounds, extracts, and mixtures compared to vehicle (1% DMSO) control. All interventions tested at 100 µg/mL
| Treatment | n | Median RLS (95% CI) | % change | Bonferroni-corrected p-value (uncorrected) |
|---|---|---|---|---|
| 1% DMSO (vehicle control) | 198 | 21 (20–24) | 0.0 | - |
| Compounds and extracts | ||||
| Alpha-lipoic acid | 40 | 21 (19–26) | 0.0 | 1 (0.859) |
| Broccoli concentrate | 80 | 19.5 (16–24) | − 7.2 | 1 (0.342) |
| Choline bitartrate | 160 | 21 (19–23) | 0.0 | 1 (0.820) |
| Curcumin phytosome complex | 40 | 19 (17–24) | − 9.5 | 1 (0.480) |
| Glucosamine HCl | 116 | 21 (19–25) | 0.0 | 1 (0.815) |
| Grape seed #1 | 118 | 19.5 (18–24) | − 7.2 | 1 (0.913) |
| Grape seed #2 | 80 | 20.5 (19–24) | − 2.4 | 1 (0.945) |
| Green tea | 160 | 12 (11–14) | − 42.9 | < 0.001 (< 0.001) |
| Lutein | 39 | 18 (16–28) | − 14.3 | 1 (0.984) |
| Lycopene | 118 | 19 (17–22) | − 9.5 | 1 (0.096) |
| Milk thistle | 40 | 19 (15–26) | − 9.5 | 1 (0.540) |
| N-acetyl l-cysteine | 39 | 20 (17–27) | − 4.8 | 1 (0.664) |
| Olive fruit | 80 | 20.5 (19–26) | − 2.4 | 1 (0.722) |
| Polygonum cuspidatum root | 40 | 16 (13–22) | − 23.8 | 1 (0.073) |
| Pterocarpus marsupium | 104 | 28 (25–31) | 33.3 | 0.001 (< 0.001) |
| Quercetin | 40 | 18.5 (16–27) | − 11.9 | 1 (0.836) |
| Rutin | 40 | 18.5 (15–26) | − 11.9 | 1 (0.309) |
| Turmeric | 40 | 16.5 (14–22) | − 21.4 | 0.208 (0.009) |
| Mixtures | ||||
| 1 | 80 | 25 (22–27) | 19.0 | 0.219 (0.009) |
| 2 | 40 | 18 (14–21) | − 14.3 | 1 (0.056) |
| 3 | 80 | 21 (18–23) | 0.0 | 1 (0.609) |
| 4 | 40 | 22.5 (20–26) | 7.1 | 1 (0.883) |
| 5 | 40 | 15.5 (13–21) | − 26.2 | 0.997 (0.042) |
| 6 | 40 | 20 (16–24) | − 4.8 | 1 (0.377) |