Table 6.
Median RLS (95% confidence intervals), number of cells dissected (n), percent change, and p-value (Wilcoxon rank-sum test, Bonferroni-corrected for multiple testing within each dose response) of natural products compared to vehicle control. Note: separate control used for each compound. Berberine suspended in H2O and thus compared to YPD
| Treatment | Concentration | n | Median RLS (95% CI) | % change | Bonferroni-corrected p-value |
|---|---|---|---|---|---|
| YPD | NA | 160 | 21.5 (20–23) | - | - |
| Berberine | 1 µg/mL | 155 | 22 (21–25) | 2.3 | 0.173 |
| Berberine | 10 µg/mL | 160 | 21 (20–23) | − 2.3 | 1 |
| Berberine | 50 µg/mL | 157 | 10 (9–11) | − 53.5 | < 0.001 |
| DMSO | 1% | 60 | 23.5 (21–30) | - | - |
| Celastrol | 5 µM | 60 | 24.5 (22–29) | 4.3 | 1 |
| Celastrol | 10 µM | 60 | 25 (23–29) | 6.4 | 1 |
| Celastrol | 100 µM | 60 | 23 (18–28) | − 2.1 | 0.841 |