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. 2021 Nov 4;12:753548. doi: 10.3389/fphar.2021.753548

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Copyright © 2021 Mei, Zheng, Ma, Xia, Gao, Hao, Luo and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EGCG alleviated IDD progression in a rat model by regulating the circadian clock. (A) T2-weighted MRI images of rat tails at 8 weeks after surgery. (B) Quantitative analysis of the T2 disc signal intensity. (C) Pfirrmann MRI grades for the three groups at 8 weeks post-surgery. (D) Representative H and E as well as (E) S-O staining of the punctured discs from the various groups at 8 weeks after surgery. (F) A TUNEL assay was performed conducted to assess apoptotic levels in NP samples from discs in various groups. (G) Western blot assay was conducted, and (H) protein levels of Bmal1, Collagen II, Aggrecan, MMP13, ADAMTS5, cleaved caspase3 and Bax/Bcl-2 in the NP samples of rats are shown. Data are shown as mean ± SD (n = 12). ^* p < 0.05, ^** p < 0.01.