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. 2021 Nov 4;11:729512. doi: 10.3389/fonc.2021.729512

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Copyright © 2021 Zhu, Wang, Wang, Shang, Pei, Zhao, Kong and Fan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) PCA score plot of preoperative and postoperative serum of 2-week samples in positive-ion mode with the statistical parameters (R²X = 0.965, Q² = 0.823). (B) S-plot of OPLS-DA with the statistical parameters in positive-ion mode (R²X = 0.939, R²Y = 0.639, Q2 = 0.844). (C) VIP value plot between preoperative and postoperative serum of 2-week samples in positive-ion mode. (D) Validation plot of the preoperative and postoperative serum of 2-week samples in positive-ion mode obtained from 200 permutation tests.