. Author manuscript; available in PMC: 2022 Oct 1.

Published in final edited form as: Am J Ophthalmol. 2021 Jun 5;230:156–165. doi: 10.1016/j.ajo.2021.05.019

Table 3:

Diagnostic accuracy of age-adjusted OCTA and OCT parameters based on AUC for distinguishing each diagnostic group from healthy.

	Suspect	POAG
	Suspect	Mild	Moderate	Severe	Any
Asymmetry Parameters
hdVAD	0.517	0.685	0.681	0.594	0.656
qdVAD	0.519	0.611	0.725	0.630	0.648
qdRNFL	0.488	0.473	0.525	0.497	0.497
VAD and RNFL Parameters
gVAD	0.522	0.720	0.828	0.894	0.804
Superior Hemiretinal VAD	0.579	0.697	0.832	0.872	0.789
Inferior Hemiretinal VAD	0.546	0.737	0.797	0.907	0.806
gRNFL	0.602	0.793	0.855	0.914	0.847
Combined Parameters
hdVAD + gRNFL	0.603	0.818^*	0.866	0.914	0.859^*
qdVAD + gRNFL	0.602	0.795	0.881	0.914	0.855
qdRNFL + gRNFL	0.604	0.794	0.873	0.915	0.852
gVAD + gRNFL	0.613	0.786	0.866	0.931	0.851

Statistically significantly higher (P < 0.05) than AUC of gRNFL alone for distinguishing the same diagnostic group from healthy, as determined by DeLong’s test.

Abbreviations: OCTA=optical coherence tomography angiography; OCT=optical coherence tomography; AUC=area under receiver operating curve; POAG=primary open angle glaucoma; hdVAD=superior and inferior hemiretinal absolute difference in vessel area density; qdVAD=superior and inferior quadrant absolute difference in vessel area density; qdRNFL=superior and inferior quadrant absolute difference in retinal nerve fiber layer thickness; VAD=vessel area density; RNFL=retinal nerve fiber layer thickness; gVAD=global vessel area density; gRNFL=average global retinal nerve fiber layer thickness.