Table 2:
Comparison of overall and domain specific geriatric impairment and frailty among older adults of different age group.
| Variable# | 60-64y | 65-74 y | ≥75 y | P value* |
|---|---|---|---|---|
| N | 119 | 199 | 104 | |
|
| ||||
| GA Impairment ≥2 | 78 (61.4%) | 141 (66.2%) | 79 (70.5%) | 0.33 |
|
| ||||
| GA Impairment Count (0-13), median (IQR) | 2 (1-4) | 2 (1-5) | 3 (1-6) | 0.11 |
|
| ||||
| Frailty Score, median (IQR) | 0.26 (0.13-0.41) | 0.28 (0.15-0.40) | 0.28 (0.17-0.48) | 0.29 |
|
| ||||
| Frailty Category | 0.45 | |||
| - Robust | 46 (38.2%) | 70 (34.0%) | 29 (26.6%) | |
| - Prefrail | 33 (26.8%) | 62 (30.1%) | 36 (33.0%) | |
| - Frail | 43 (35.0%) | 74 (35.9%) | 44 (40.4%) | |
|
| ||||
| IADL Impairment ≥1 | 60 (47.2%) | 111 (52.1%) | 66 (58.9%) | 0.20 |
|
| ||||
| ADL Impairment ≥1 | 26 (20.5%) | 42 (19.7%) | 27 (24.1%) | 0.64 |
|
| ||||
| ECOG Performance Status ≥2 | 40 (33.6%) | 65 (25.3%) | 29 (27.1%) | 0.61 |
|
| ||||
| ≥1 Falls in 6 months | 24 (18.9%) | 37 (17.6%) | 27 (24.1%) | 0.34 |
|
| ||||
| Malnutrition | 55 (43.3%) | 103 (48.4%) | 56 (50%) | 0.54 |
|
| ||||
| Cognitive Impairment | 11 (8.7%) | 12 (5.6%) | 9 (8.0%) | 0.54 |
|
| ||||
| Anxiety | 23 (18.1%) | 44 (20.7%) | 17 (15.2%) | 0.50 |
|
| ||||
| Depression | 19 (15.0%) | 26 (12.2%) | 15 (13.4%) | 0.75 |
|
| ||||
| ≥3 Comorbidities | 48 (39.0%) | 112 (56.3%) | 59 (55.7%) | 0.006 |
|
| ||||
| ≥9 Medications | 23 (19.0%) | 50 (25.3%) | 29 (27.1%) | 0.29 |
GA, Geriatric Impairment; IADL, Instrumental Activities of Daily Living; ADL, Activities of Daily Living; ECOG, Eastern Co-operative Oncology Group.
N reflects number of patients with available data to calculate the number of GA impairments. Patients were required to have non-missing information on at least 11 domains (85%) to have a valid result.
Represents unadjusted P values. Additional sensitivity analyses were done accounting for marital support and cancer stage (Mantel-Haenszel test using marital support and cancer stage as stratifying variables in case of categorical variables, Poisson and linear regression for GA Impairment count and Frailty Score respectively, controlling for marital support and cancer stage), however the results remained unchanged (results not shown)
Separate pairwise comparisons were conducted between age group 60-64y vs 65-74y and 60-64y vs ≥75y, with overall similar findings with the exception of higher comorbidity burden in the higher age group (results not shown).