Table 2.
Cox Regression on Mortality in ALM patients
| Covariate | Hazard Ratio (95% CI) | p-value |
|---|---|---|
| Age | ||
| < 60 years | Reference | |
| ≥ 60 years | 1.92 (1.59, 2.32) | <0.01 |
| Sex | ||
| Male | 1.40 (1.20, 1.64) | <0.01 |
| Female | Reference | |
| Race | ||
| White | Reference | |
| Black | 1.11 (0.87, 1.42) | 0.41 |
| Other | 0.89 (0.60, 1.33) | 0.57 |
| Charlson-Deyo Comorbidity Index | ||
| 0 | Reference | |
| 1 | 1.01 (0.83, 1.24) | 0.93 |
| 2–3 | 1.76 (1.30, 2.39) | <0.01 |
| Year of Diagnosis | ||
| 2004–2010 | 1.18 (1.00, 1.39) | 0.05 |
| 2011–2015 | Reference | |
| Tumor thickness (T stage) | ||
| T1: <=1.0mm | Reference | |
| T2: 1.01 – 2.0mm | 1.37 (0.91, 2.06) | 0.13 |
| T3: 2.01 – 4mm | 2.00 (1.35, 2.98) | <0.01 |
| T4: >4mm | 3.29 (2.22, 4.88) | <0.01 |
| Ulceration | ||
| Yes | 1.45 (1.23, 1.72) | <0.01 |
| No | Reference | |
| Positive lymph nodes × Years | <0.01 | |
| ≥1 vs none, at ≤1 year | 3.40 (2.55, 4.55) | <0.01 |
| ≥1 vs none, at 1.01 to 2 years | 2.75 (2.25, 3.37) | <0.01 |
| ≥1 vs none, at 2.01 to 3 years | 2.23 (1.88, 2.65) | <0.01 |
| ≥1 vs none, at 3.01 to 4 years | 1.80 (1.44, 2.26) | <0.01 |
| ≥1 vs none, at 4.01 to 5 years | 1.46 (1.05, 2.02) | 0.02 |
| Metastasis | ||
| M0 | Reference | |
| M1 | 2.73 (1.79, 4.16) | <0.01 |
| Surgery | ||
| Amputation | 1.17 (0.93, 1.48) | 0.19 |
| Wide local excision | 0.91 (0.75, 1.10) | 0.33 |
| Local excision/biopsy | Reference | |
| Surgical margin status at any COC facility | ||
| Positive | 1.07 (0.79, 1.45) | 0.67 |
| Negative | Reference | |
| Chemotherapy | ||
| Yes | 0.84 (0.53, 1.31) | 0.43 |
| No | Reference | |
| Immunotherapy | ||
| Yes | 0.79 (0.63, 1.00) | 0.05 |
| No | Reference | |
| Radiation | ||
| Yes | 0.97 (0.65, 1.44) | 0.87 |
| No | Reference |