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. 2021 Nov 17;11:22463. doi: 10.1038/s41598-021-01943-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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High neutrophil to lymphocyte ratio is associated with an increased number of DEspR^high neutrophils. (A) Neutrophil–lymphocyte ratio (NLR) in control (n = 12) and COVID-19 (n = 26) subjects. Mann–Whitney test. (B) Relationship between NLR and number of DEspR^high neutrophils. Spearman correlation coefficient is indicated. (C–E) Number of (C) CD3 T lymphocytes, (D) CD3/CD4 and (E) CD3/CD8 T cells in control and COVID-19 subjects. Mann–Whitney test. (F–H) Association between the number of DEspR^high neutrophils and (F) total T lymphocytes, (G) CD3/CD4, and (H) CD3/CD8 T cells. Spearman correlation coefficients and P values are indicated.