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. 2021 Nov 17;11:22386. doi: 10.1038/s41598-021-01899-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Compliance calculated as the average number of days per week that the patients were using the treatment. Smoothed conditional mean compliance were fitted using loess method for each treatment. 95% confidence bands were shown as shaded ribbon in respective colors. Figure created in R version 4.0 with ggplot2 package, version 3.3.5 (The R Foundation for Statistical Computing, Welthandelsplatz 1, 1020 Vienna, Austria).