Table 1.

SCO Amplitude and Frequency Response to AMPAR Antagonist PERAMP or GABAAR PAM MDZ Added to Mouse Hippocampal Neuronal Cultures Exposed to 3 µM TETS at DIV 14–16

Treatment	Mean (% of Vehicle)	SEM	95% CI		Vs Vehicle p	Vs TETS p
			Upper	Lower
SCO frequency: PERAMP
Vehicle	100.00	2.57	105.19	94.79		.0021
TETS	76.25	3.82	83.98	68.52	.0021
0.1 µM PERAMP + TETS	48.68	5.46	60.39	36.97	<.0001	.0177
0.3 µM PERAMP + TETS	25.63	6.06	38.62	12.63	<.0001	<.0001
1.0 µM PERAMP + TETS	21.40	6.07	34.43	8.37	<.0001	<.0001
3.0 µM PERAMP + TETS	4.43	2.46	9.70	0.00	<.0001	<.0001
SCO amplitude: PERAMP
Vehicle	100.00	2.69	105.36	94.64		<.0001
TETS	197.79	15.63	228.94	166.64	<.0001
0.1 µM PERAMP + TETS	108.75	6.57	122.85	94.66	.7398	.0007
0.3 µM PERAMP + TETS	93.48	30.20	158.25	28.70	.8044	<.0001
1.0 µM PERAMP + TETS	59.75	15.61	93.23	26.28	.1269	<.0001
3.0 µM PERAMP + TETS	16.87	9.05	36.27	0.00	.0017	<.0001
SCO frequency: MDZ
Vehicle	100.00	2.57	105.19	94.79		.0021
TETS	76.25	3.82	83.98	68.52	.0021
1.0 µM MDZ + TETS	82.92	3.44	90.69	75.15	.1963	.6144
3.0 µM MDZ + TETS	80.08	4.68	90.68	69.49	.0985	.7721
6.0 µM MDZ + TETS	84.86	5.55	97.42	72.31	.1971	.5153
10.0 µM MDZ + TETS	41.86	6.69	57.68	26.03	<.0001	.0179
SCO amplitude: MDZ
Vehicle	100.00	2.69	105.36	94.64		<.0001
TETS	197.79	15.63	228.94	166.64	<.0001
1.0 µM MDZ + TETS	125.99	5.81	139.13	112.86	.407	.0221
3.0 µM MDZ + TETS	98.13	8.74	117.90	78.36	.9523	.0015
6.0 µM MDZ + TETS	53.46	5.38	65.63	41.29	.1378	<.0001
10.0 µM MDZ + TETS	11.88	2.71	18.13	5.62	.0074	<.0001