Table 2.
SCO Frequency and Amplitude Response to 5 NAS Added to Mouse Hippocampal Neuronal Cultures Are Exposed to 3 µM TETS at DIV 14–16
| Treatment | Mean (% of Vehicle) | SEM | 95% CI |
Vs Vehicle p | Vs TETS p | |
|---|---|---|---|---|---|---|
| Upper | Lower | |||||
| SCO frequency: 0.1 µM NAS | ||||||
| Vehicle | 100.00 | 2.57 | 105.19 | 94.79 | .0021 | |
| TETS | 76.25 | 3.82 | 83.98 | 68.52 | .0021 | |
| ALLO + TETS | 66.28 | 2.27 | 71.16 | 61.41 | .002 | .3901 |
| ELTAN + TETS | 120.92 | 16.51 | 156.34 | 85.50 | .0968 | .0001 |
| GANAX + TETS | 111.57 | 19.11 | 152.85 | 70.29 | .4085 | .0031 |
| ALPHAX + TETS | 121.73 | 22.44 | 172.49 | 70.97 | .1395 | .0008 |
| XJ-42 + TETS | 111.97 | 13.25 | 140.38 | 83.56 | .3774 | .0021 |
| SCO frequency: 0.3 µM NAS | ||||||
| Vehicle | 100.00 | 2.57 | 105.19 | 94.79 | .0021 | |
| TETS | 76.25 | 3.82 | 83.98 | 68.52 | .0021 | |
| ALLO + TETS | 76.24 | 8.23 | 94.02 | 58.46 | .0289 | .9991 |
| ELTAN + TETS | 105.01 | 12.98 | 132.85 | 77.17 | .7799 | .0126 |
| GANAX + TETS | 112.75 | 20.69 | 157.45 | 68.06 | .3499 | .0021 |
| ALPHAX + TETS | 136.35 | 15.15 | 170.62 | 102.08 | .0099 | <.0001 |
| XJ-42 + TETS | 119.83 | 18.21 | 158.87 | 80.78 | .1143 | .0002 |
| SCO frequency: 1.0 µM NAS | ||||||
| Vehicle | 100.00 | 2.57 | 105.19 | 94.79 | .0021 | |
| TETS | 76.25 | 3.82 | 83.98 | 68.52 | .0021 | |
| ALLO + TETS | 73.97 | 1.64 | 77.48 | 70.46 | .0147 | .8427 |
| ELTAN + TETS | 139.38 | 5.98 | 152.20 | 126.55 | .001 | <.0001 |
| GANAX + TETS | 88.32 | 10.64 | 111.30 | 65.34 | .2478 | .3062 |
| ALPHAX + TETS | 135.82 | 8.79 | 155.70 | 115.93 | .0111 | <.0001 |
| XJ-42 + TETS | 121.49 | 15.25 | 154.19 | 88.79 | .0846 | <.0001 |
| SCO frequency: 3.0 µM NAS | ||||||
| Vehicle | 100.00 | 2.57 | 105.19 | 94.79 | .0021 | |
| TETS | 76.25 | 3.82 | 83.98 | 68.52 | .0021 | |
| ALLO + TETS | 110.51 | 3.82 | 118.71 | 102.31 | .4456 | .003 |
| ELTAN + TETS | 127.98 | 24.18 | 179.85 | 76.11 | .022 | <.0001 |
| GANAX + TETS | 139.84 | 16.47 | 175.42 | 104.26 | .0012 | <.0001 |
| ALPHAX + TETS | 137.78 | 31.82 | 211.15 | 64.41 | .0101 | <.0001 |
| XJ-42 + TETS | 100.14 | 4.20 | 109.21 | 91.06 | .885 | .0431 |
| SCO Amplitude: 0.1 µM NAS | ||||||
| Vehicle | 100.00 | 2.69 | 105.36 | 94.64 | <.0001 | |
| TETS | 197.79 | 15.63 | 228.94 | 166.64 | <.0001 | |
| ALLO + TETS | 138.30 | 6.47 | 152.18 | 124.43 | .1539 | .0267 |
| ELTAN + TETS | 157.53 | 11.29 | 182.14 | 132.92 | .0438 | .1576 |
| GANAX + TETS | 186.51 | 11.37 | 211.08 | 161.95 | .0018 | .6827 |
| ALPHAX + TETS | 160.48 | 9.44 | 181.84 | 139.12 | .0585 | .2424 |
| XJ-42 + TETS | 277.81 | 62.50 | 411.85 | 143.76 | <.0001 | .0029 |
| SCO amplitude: 0.3 µM NAS | ||||||
| Vehicle | 100.00 | 2.69 | 105.36 | 94.64 | <.0001 | |
| TETS | 197.79 | 15.63 | 228.94 | 166.64 | <.0001 | |
| ALLO + TETS | 126.57 | 6.89 | 141.45 | 111.69 | .3254 | .0085 |
| ELTAN + TETS | 215.63 | 38.16 | 298.07 | 133.20 | <.0001 | .5085 |
| GANAX + TETS | 170.72 | 8.77 | 189.82 | 151.63 | .0113 | .3309 |
| ALPHAX + TETS | 108.57 | 11.42 | 134.40 | 82.74 | .7837 | .0043 |
| XJ-42 + TETS | 228.05 | 42.19 | 318.54 | 137.56 | <.0001 | .2485 |
| SCO amplitude: 1.0 µM NAS | ||||||
| Vehicle | 100.00 | 2.69 | 105.36 | 94.64 | <.0001 | |
| TETS | 197.79 | 15.63 | 228.94 | 166.64 | <.0001 | |
| ALLO + TETS | 118.96 | 6.47 | 132.84 | 105.09 | .4699 | .0027 |
| ELTAN + TETS | 91.87 | 14.00 | 121.89 | 61.85 | .7567 | <.0001 |
| GANAX + TETS | 173.76 | 12.05 | 199.79 | 147.72 | .0065 | .373 |
| ALPHAX + TETS | 50.60 | 5.72 | 63.54 | 37.66 | .1138 | <.0001 |
| XJ-42 + TETS | 211.47 | 50.11 | 318.93 | 104.00 | <.0001 | .6019 |
| SCO amplitude: 3.0 µM NAS | ||||||
| R Vehicle | 100.00 | 2.69 | 105.36 | 94.64 | <.0001 | |
| TETS | 197.79 | 15.63 | 228.94 | 166.64 | <.0001 | |
| ALLO + TETS | 75.11 | 4.37 | 84.64 | 65.59 | .3718 | <.0001 |
| ELTAN + TETS | 40.48 | 4.68 | 50.53 | 30.44 | .0236 | <.0001 |
| GANAX + TETS | 69.97 | 16.81 | 106.28 | 33.66 | .2662 | <.0001 |
| ALPHAX + TETS | 25.59 | 3.30 | 33.06 | 18.12 | .0173 | <.0001 |
| XJ-42 + TETS | 59.17 | 4.96 | 69.89 | 48.45 | .1308 | <.0001 |