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. 2021 Jun 25;49(20):11407–11424. doi: 10.1093/nar/gkab515

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — DEN1-NS1 variant detection in 22 Singaporean clinical samples by the aptamer−antibody ELISA formats. (A) Differences in the amino acid sequences of DEN1-NS1 proteins derived from the 22 clinical samples (PD1-1 through PD1-22) in Singapore and the original DEN1-NS1 target from The Native Antigen Company (Native Antigen / NAD1). The sequence identities (%) are presented as compared to NAD1 (left column) and PD1-2/1-3 (right column). (B) The DEN-NS1 variant detection by our ELISA formats, using aptamer (AptD1 or AptD1b) and antibody (Ab#D06) pairs and an antibody (Ab#D25) and antibody (Ab#D06) pair. Alere's LFA (Panbio Dengue Duo Cassette for IgM and IgG) assigned PD1-1, PD1-9, PD1-14 and PD1-19 as the secondary DENV infected samples. The amino-acid sequence identities, Seq. Identity (%), with DEN1-NS1 in PD1-2 and with NAD are shown at the bottom of the graph.