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. 2021 Oct 28;49(20):11666–11689. doi: 10.1093/nar/gkab964

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — ID3 low expression is associated with impaired HR in cancer patients. (A) Box plot representation showing the single sample GSVA enrichment score of GO: regulation of double strand break via homologous repair in clusters of patient samples of TCGA prostate adenocarcinoma (PRAD). (B) Box plot representation showing the single sample GSVA enrichment score of GO: double strand break repair via break-induced replication in clusters of patient samples of TCGA PRAD. (C) Box plot representation showing ID3 expression as log₂ counts per million in clusters of patient samples of TCGA PRAD. (D) Box plot representation showing the single sample GSVA enrichment score of GO: regulation of double strand break via homologous repair in clusters of patient samples of TCGA testicular germ cell tumors (TGCT). (E) Box plot representation showing the single sample GSVA enrichment score of GO: double strand break repair via break-induced replication in clusters of patient samples of TCGA TCGT. (F) Box plot representation showing ID3 expression as log₂ counts per million in clusters of patient samples of TCGA TGCT. (G) Box plot representation showing the single sample GSVA enrichment score of GO: regulation of double strand break via homologous repair in clusters of patient samples of TCGA low grade glioma (LGG). (H) Box plot representation showing the single sample GSVA enrichment score of GO: double strand break repair via break-induced replication in clusters of patient samples of TCGA LGG. (I) Box plot representation showing ID3 expression as log₂ counts per million in clusters of patient samples of TCGA LGG patient samples. Group comparisons were performed using an unpaired Wilcoxon rank test. The dotted lines in all panels represent the average score across all groups. All group comparisons were performed using an unpaired Wilcoxon rank test. (J) Bubble plot representation showing the Pearson correlation coefficient between the expression of DNA repair genes (BRCA1, BRCA2, RAD51, EXO1, RBBP8, FANCM, PRMT5, TFDP1 and E2F1) and ID3 in clusters of TCGA patient samples of PRAD (top), TGCT (middle) and LGG (bottom). Empty squares represent no significant correlation (P > 0.05). The color of the circles represent the degree of correlation (red: positive; blue: negative) and the larger the size of the circle the stronger the significance.