TABLE 2.
Overrepresented gene ontology (GO) annotations for alcohol-upregulated genes.
| Rank | Enriched gene ontology terms (upregulated genes) | Fold enrichment | Fisher exact score | Genes |
| 1 | Histone H3 acetylation | 20.80 | 3.90E-04 | CG6907, Sgf29, trx |
| 2 | Regulation of calcium ion-dependent exocytosis | 60.09 | 4.50E-04 | Sec23, Ank |
| 3 | Protein targeting to plasma membrane | 60.09 | 4.50E-04 | Syt1, Syt7 |
| 4 | Calcium ion-regulated exocytosis of neurotransmitter | 45.07 | 8.30E-04 | Syt1, Syt7 |
| 5 | Response to hyperoxia | 40.06 | 1.10E-03 | CG33129, Tm1 |
| 6 | Basement membrane organization | 36.05 | 1.30E-03 | Sec23, Pten |
| 7 | Larval chitin-based cuticle development | 22.53 | 3.50E-03 | Sec23, Lcp9 |
| 8 | Endoplasmic reticulum organization | 21.21 | 3.90E-03 | Sec23, Rtnl1 |
| 9 | Regulation of establishment of planar polarity | 21.21 | 3.90E-03 | Akap200, Pten |
| 10 | Positive regulation of dendrite morphogenesis | 18.97 | 4.90E-03 | Sec23, G9a |
| 11 | Chemical synaptic transmission | 8.19 | 5.80E-03 | CaMKII, sky, Syt1 |
| 12 | Long-term memory | 7.51 | 7.40E-03 | CaMKII, spoon, G9a |
| 13 | Neurotransmitter secretion | 6.08 | 1.30E-02 | Syt1, nSyb, Syt7 |
| 14 | Sensory perception of pain | 2.40 | 1.70E-02 | CtBP, CaMKII, Akap200, stj, trx, rn, TRAM, CG5757 |
Gene ontology annotations within the “biological process” category that were enriched in alcohol-upregulated genes were identified using DAVID. For each term, fold enrichment, fisher exact scores, and the names of associated genes identified are listed.