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. 2021 Nov 17;4:1298. doi: 10.1038/s42003-021-02818-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Fuzzy c-means clustering of the differential open chromatin peaks (ATAC-seq) during pancreatic differentiation of HUES8 cells. b TF binding motif enrichment at distinct open chromatin clusters of ATAC-seq. c Average chromatin accessibility profiles around footprint-supported bindings sites of selected TFs. d Heatmap ChIP-seq signals (+/− 5 kb of peak center) of H3K4me1, H3K4me3, and H3K27ac at ATAC-seq peaks from cluster PE-PP (VIII; clustering is shown in Fig. 2a). Peaks are ordered by the decrease in the H3K4me1 mark at PE stage. We also depict ONECUT1 ChIP-seq signals (PP stage) in the vicinity of the peak (+/− 5 kb).