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. 2021 Nov 17;12:6655. doi: 10.1038/s41467-021-26821-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a T-cell density—an estimate of the proportion of T cells in a specimen, b T-cell richness—a measure of T-cell diversity and (c) T-cell clonality—a metric indicating T-cell expansion and reactivity, were derived from 19 SCLCs (red) versus 236 NSCLCs (blue) from the PROSPECT cohort. TCR intratumor heterogeneity (ITH) in 10 SCLC versus 11 NSCLC using (d) the average Jaccard index (JI), a metric representing the proportion of shared T-cell clonotypes, e Morisita index (MOI), a metric taking into consideration not only the composition of T-cell clonotypes but also the abundance of individual T-cell clonotypes and (f) proportion of shared top 20 TCR clonotypes between any paired samples within the same tumors in SCLC (blue) versus NSCLC tumors (red) with multiregional TCR data available. The difference of TCR metrics between SCLC and NSCLC was evaluated using two-sided Mann–Whitney test. Source data are provided as a Source Data file.