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. 2021 Nov 17;12:6655. doi: 10.1038/s41467-021-26821-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Tumor purity in SCLCs versus NSCLCs. Tumor purity was derived from whole-exome sequencing (WES) data from 19 SCLC tumors (blue) versus 242 NSCLC tumors (red) from the PROSPECT cohort. b T-cell infiltration in SCLCs compared with NSCLCs. T-cell infiltration was derived by deconvolution of RNA sequencing (RNA-seq) data of 81 SCLC tumors (George cohort) versus 1027 NSCLC tumors from TCGA. c Immune score in SCLCs compared with NSCLCs. The immune score was calculated from RNA-seq data to quantify all immune cells within the tumors from 81 SCLC tumors (George cohort) versus 1027 NSCLC tumors from TCGA. d CD3 + tumor-infiltrating lymphocytes (TILs) of SCLC (n = 67) versus NSCLC (n = 68) tumors by immunohistochemistry (IHC). The y axis represents CD3 + TILs: tumor-cell ratio. e Association of tumor purity with CD3 + TILs in SCLCs (n = 19). The y axis represents CD3 + TILs: tumor-cell ratio. f Expression of programmed death ligand-1 (PD-L1) by IHC in SCLC (n = 67) versus NSCLC (n = 68) tumors. The difference of immune features between SCLC and NSCLC was evaluated using two-sided Mann–Whitney test. The correlation coefficient (r) of tumor purity with CD3 + TILs was assessed by two-tailed Spearman’s rank-correlation test. Source data are provided as a Source Data file.