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. 2021 Nov 17;12:6655. doi: 10.1038/s41467-021-26821-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Copy number loss of IFN-γ pathway genes in 50 SCLC samples from 19 SCLC patients. Purple patient IDs = alive; Green patient IDs = deceased. b Copy-number loss burden of IFN-γ pathway genes in 50 SCLC samples (blue) versus 327 NSCLC samples (red) from TRACERx. c Correlation of copy number alteration (CNA) burden of IFN-γ pathway genes with overall CNA burden in SCLC (n = 50). The difference of copy number loss burden of IFN-γ pathway genes between SCLC and NSCLC was evaluated using two-sided Mann–Whitney test. The correlation coefficient (r) of CNA burden of IFN-γ pathway genes with overall CNA burden was assessed by two-tailed Spearman’s rank-correlation test. Source data are provided as a Source Data file.