Table 1.
Demographics and baseline characteristics
| Overall (N = 2345) | 30>BMI (N = 1168) | 35>BMI ≥ 30 (N = 646) | BMI ≥ 35 (N = 531) | P-value | |
|---|---|---|---|---|---|
| Follow-up (years), median (IQR) | 5.4 (4.6–6.8) | 5.5 (4.5–6.8) | 5.5 (4.7–6.9) | 5.2 (4.5–6.6) | 0.08 |
| Age (years), mean ± SD | 63 ± 11 | 64 ± 11 | 62 ± 11 | 59 ± 11 | <0.001 |
| Female, n (%) | 1102 (47) | 509 (44) | 288 (45) | 305 (57) | <0.001 |
| Height (m), mean ± SD | 1.70 ± 0.11 | 1.71 ± 0.10 | 1.70 ± 0.11 | 1.68 ± 0.11 | <0.001 |
| Weight (kg), mean ± SD | 90 ± 22 | 76 ± 13 | 94 ± 12 | 116 ± 21 | <0.001 |
| BMI (kg/m2), mean ± SD | 31 ± 7 | 26 ± 2.9 | 32 ± 1.4 | 41 ± 5.9 | <0.001 |
| Cardiac risk factors, n (%) | |||||
| Hypertension | 1841 (79) | 881 (75) | 512 (79) | 448 (84) | <0.001 |
| Hypercholesterolaemia | 1644 (70) | 843 (72) | 446 (69) | 355 (67) | 0.07 |
| Diabetes mellitus | 664 (28) | 253 (22) | 193 (30) | 218 (41) | <0.001 |
| Smoking | 757 (33) | 374 (32) | 193 (30) | 190 (36) | 0.09 |
| Family history of CAD | 761 (34) | 387 (35) | 196 (32) | 178 (35) | 0.39 |
| History of PCI, n (%) | 538 (23) | 275 (24) | 150 (23) | 113 (21) | 0.61 |
| History of MI, n (%) | 357 (15) | 201 (17) | 98 (15) | 58 (11) | 0.005 |
| History of HF, n (%) | 245 (10) | 119 (10) | 64 (10) | 62 (12) | 0.54 |
| Stress CMR | |||||
| Required sedation, n (%) | 50 (2) | 22 (2) | 15 (2) | 13 (2) | 0.70 |
| Magnet field strength | |||||
| 1.5 T, n (%) | 1532 (65) | 755 (65) | 384 (59) | 393 (74) | <0.001 |
| 3.0 T, n (%) | 813 (35) | 413 (35) | 262 (41) | 138 (26) | — |
| Bore size | |||||
| 60 cm, n (%) | 1630 (70) | 846 (72) | 479 (74) | 305 (57) | <0.001 |
| 70 cm, n (%) | 715 (30) | 322 (28) | 167 (26) | 226 (43) | — |
| Quality of cine sequence | |||||
| Score, median (IQR) | 5 (4–5) | 5 (4–5) | 5 (4–5) | 5 (4–5) | 0.09 |
| Score 3–5, n (%) | 2335 (100) | 1165 (100) | 643 (100) | 527 (99) | 0.34 |
| Score 1–2, n (%) | 10 (0) | 3 (0) | 3 (0) | 4 (1) | — |
| Quality of perfusion sequence | |||||
| Score, median (IQR) | 5 (4–5) | 5 (4–5) | 5 (4–5) | 5 (4–5) | 0.07 |
| Score 3–5, n (%) | 2251 (100) | 1111 (100) | 622 (100) | 518 (99) | 0.36 |
| Score 1–2, n (%) | 10 (0) | 3 (0) | 3 (0) | 4 (2) | — |
| Quality of LGE sequence | |||||
| Score, median (IQR) | 5 (4–5) | 5 (4–5) | 5 (4–5) | 5 (4–5) | 0.01 |
| Score 3–5, n (%) | 2252 (99) | 1112 (100) | 621 (99) | 519 (99) | 0.33 |
| Score 1–2, n (%) | 11 (1) | 3 (0) | 4 (1) | 4 (1) | — |
| LVEF (%), median (IQR) | 63 (54–70) | 62 (54–69) | 64 (55–71) | 64 (56–71) | 0.009 |
| Inducible ischaemia, n (%) | 405 (17) | 244 (21) | 90 (14) | 71 (13) | <0.001 |
| Ischaemic segments | |||||
| Mild (1–2), n (%) | 175 (8) | 102 (9) | 38 (6) | 35 (7) | 0.001 |
| Moderate (3–5), n (%) | 128 (5) | 82 (7) | 26 (4) | 20 (4) | — |
| Severe (≥ 6), n (%) | 102 (4) | 60 (5) | 26 (4) | 16 (3) | — |
| Prior infarct by LGE, n (%) | 572 (24) | 312 (27) | 154 (24) | 106 (20) | 0.01 |
| Ischaemia or LGE, n (%) | 766 (33) | 422 (36) | 199 (31) | 145 (27) | 0.001 |
BMI, body mass index; CMR, cardiovascular magnetic resonance; CAD, coronary artery disease; HF, heart failure; IQR, inter-quartile range; LVEF, left ventricular ejection fraction; LGE, late gadolinium enhancement; MI, myocardial infarction; PCI, percutaneous coronary intervention.