Table 2.
Univariable and multivariable cox association of clinical and stress cardiac magnetic resonance indices with primary outcome in patients with obesity
| Characteristics | Univariable |
Multivariable |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Demographics | ||||||
| Age (per year) | 1.02 | 1.00–1.04 | 0.03 | 1.03 | 1.01–1.05 | 0.009 |
| Female | 0.53 | 0.33–0.83 | 0.006 | — | ||
| BMI (per 1 kg/m2) | 1.01 | 0.97–1.05 | 0.62 | 1.02 | 0.98–1.06 | 0.27 |
| Cardiac risk factors | ||||||
| Hypertension | 2.04 | 0.98–4.23 | 0.06 | — | ||
| Hypercholesterolaemia | 1.26 | 0.77–2.06 | 0.36 | — | ||
| Diabetes mellitus | 1.69 | 1.09–2.63 | 0.02 | — | ||
| Smoking | 2.40 | 1.54–3.75 | <0.001 | 1.97 | 1.25–3.10 | 0.003 |
| Family history of CAD | 0.69 | 0.41–1.17 | 0.17 | — | ||
| History of PCI | 2.69 | 1.72–4.20 | <0.001 | — | ||
| History of MI | 4.27 | 2.70–6.75 | <0.001 | 1.98 | 1.20–3.27 | 0.008 |
| History of HF | 4.18 | 2.57–6.81 | <0.001 | 2.36 | 1.42–3.92 | 0.001 |
| Stress CMR | ||||||
| LVEF (per +5% Δ) | 0.82 | 0.77–0.88 | <0.001 | — | ||
| Presence of inducible ischaemia | 3.86 | 2.43–6.12 | <0.001 | 2.14 | 1.30–3.50 | 0.003 |
| Extent of ischaemia (per segment) | 1.10 | 1.04–1.16 | 0.001 | — | ||
| Presence of LGE | 5.81 | 3.70–9.11 | <0.001 | 3.09 | 1.83–5.22 | <0.001 |
| Extent of LGE (per segment) | 1.12 | 1.08–1.17 | <0.001 | — | ||
BMI, body mass index; CMR, cardiovascular magnetic resonance; CI, confidence interval; CAD, coronary artery disease; HF, heart failure; HR, hazard ratio; LVEF, left ventricular ejection fraction; LGE, late gadolinium enhancement; MI, myocardial infarction; PCI, percutaneous coronary intervention.