Table 3.
Univariable and multivariable Cox association of clinical and stress cardiac magnetic resonance indices with secondary outcome in patients with obesity
| Characteristics | Univariable |
Multivariable |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Demographics | ||||||
| Age (per year) | 1.01 | 1.00–1.02 | 0.11 | 1.01 | 1.00–1.03 | 0.13 |
| Female | 0.82 | 0.61–1.11 | 0.19 | — | ||
| BMI (per 1 kg/m2) | 1.02 | 0.99–1.04 | 0.14 | 1.03 | 1.00–1.05 | 0.04 |
| Cardiac risk factors | ||||||
| Hypertension | 2.17 | 1.31–3.57 | 0.002 | — | ||
| Hypercholesterolemia | 1.44 | 1.03–2.03 | 0.04 | — | ||
| Diabetes mellitus | 1.49 | 1.11–2.02 | 0.009 | — | ||
| Smoking | 1.69 | 1.25–2.29 | 0.001 | 1.41 | 1.04–1.91 | 0.03 |
| Family history of CAD | 0.95 | 0.68–1.32 | 0.75 | — | ||
| History of PCI | 2.96 | 2.19–4.00 | <0.001 | — | ||
| History of MI | 3.24 | 2.34–4.48 | <0.001 | 1.89 | 1.32–2.73 | 0.001 |
| History of HF | 3.10 | 2.19–4.41 | <0.001 | 2.16 | 1.50–3.11 | <0.001 |
| Stress CMR | ||||||
| LVEF (per +5% Δ) | 0.84 | 0.80–0.88 | <0.001 | — | ||
| Presence of inducible ischaemia | 3.52 | 2.55–4.84 | <0.001 | 2.27 | 1.61–3.19 | <0.001 |
| Extent of ischaemia (per segment) | 1.11 | 1.07–1.15 | <0.001 | — | ||
| Presence of LGE | 3.89 | 2.89–5.24 | <0.001 | 2.28 | 1.61–3.23 | <0.001 |
| Extent of LGE (per segment) | 1.09 | 1.06–1.12 | <0.001 | — | ||
BMI, body mass index; CMR, cardiovascular magnetic resonance; CI, confidence interval; CAD, coronary artery disease; HR, hazard ratio; HF, heart failure; LVEF, left ventricular ejection fraction; LGE, late gadolinium enhancement; MI, myocardial infarction; PCI, percutaneous coronary intervention.