Table 2.

Association between IBD/CD/UC diagnosis and PRS in univariate and multivariate analyses

Dependent variable	N a (cases + controls)	Regressor	GWAS P-value threshold	Univariate regression			Multivariate regression
				OR	95% CI	P-value	OR	95% CI	P-value
IBD	1246	PRSDrnkWk	1E-3	0.61	0.49–0.76	1.00E-05	0.76	0.59–0.98	0.0375
	1246	PRSSmkCes	1E-1	1.73	1.41–2.13	1.44E-07	1.28	0.98–1.69	0.075
	1246	PRSAgeSmk	1E-1	1.54	1.27–1.87	1.31E-05	1.19	0.92–1.52	0.179
	1246	PRSIBD	1E-3	4.01	3.11–5.18	1.43E-26	3.63	2.79–4.73	6.84E-22
CD	816	PRSDrnkWk	1E-3	0.58	0.46–0.73	5.50E-06	0.73	0.55–0.97	0.0312
	816	PRSSmkCes	1E-1	1.73	1.39–2.15	8.39E-07	1.40	1.04–1.90	0.0291
	816	PRSAgeSmk	1E-1	1.48	1.21–1.80	1.02E-04	1.06	0.82–1.38	0.636
	816	PRSCD	1E-3	4.48	3.37–5.95	4.74E-25	4.22	3.10–5.75	9.21E-20
UC	618	PRSDrnkWk	1E-3	0.64	0.51–0.82	3.19E-04	0.81	0.61–1.07	0.141
	618	PRSSmkCes	1E-1	1.70	1.35–2.13	4.93E-06	1.23	0.91–1.67	0.17
	618	PRSAgeSmk	1E-1	1.63	1.30–2.05	2.61E-05	1.23	0.92–1.66	0.159
	618	PRSUC	1E-3	3.35	2.51–4.47	2.56E-16	3.63	2.68–4.93	1.58E-16

The multivariate regression models (Models (1–3)) were specified in the Materials and Methods section. All PRSs were centered and scaled to have median = 0 and IQR = 1. In constructing PRS, the GWAS P-value thresholds were selected to maximize significance of the association between the PRS and IBD diagnosis in univariate regression analysis.

^aAnalyses for all 3 dependent variables share the same 188 HC.