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. 2020 Sep 16;113(4):381–389. doi: 10.1093/jnci/djaa141

Table 3.

Pooled association between diabetes duration and cancer incidence (NHS: 1978-2014; HPFS: 1988-2014)a

Cancer outcomes Diabetes duration
No diabetes 0-2.0 years 2.1-4.0 years 4.1-6.0 years 6.1-8.0 years 8.1-10.0 years 10.1-15.0 years >15.0 years
Total cancer
 Case/person-year 39 902/4 052 767 742/47 747 503/35 168 524/31 214 503/27 103 380/22 500 681/40 008 614/37 058
 Multivariable adjusted model, HR (95% CI)b (Referent) 1.34 (1.25 to 1.45) 1.18(1.08 to 1.30) 1.34 (1.23 to 1.47) 1.44 (1.32 to 1.58) 1.28 (1.15 to 1.42) 1.23 (1.13 to 1.33) 1.10 (1.01 to 1.20)
 Additionally adjusted for BMI, HR (95% CI)c (Referent) 1.29 (1.19 to 1.38) 1.13 (1.03 to 1.24) 1.28 (1.17 to 1.40) 1.37 (1.25 to 1.50) 1.21 (1.09 to 1.35) 1.16 (1.07 to 1.26) 1.04 (0.95 to 1.14)
Obesity-related cancerd
 Case/person-year 19 844/4 068 736 433/48 003 278/35 340 287/31 399 274/27 256 192/22 634 358/40 226 311/37 262
 Multivariable adjusted model, HR (95% CI)b (Referent) 1.53 (1.39 to 1.68) 1.29 (1.14 to 1.46) 1.47 (1.30 to 1.65) 1.59 (1.40 to 1.80) 1.31 (1.13 to 1.52) 1.32 (1.18 to 1.47) 1.15 (1.02 to 1.30)
 Additionally adjusted for BMI, HR (95% CI)c (Referent) 1.42 (1.28 to 1.56) 1.19 (1.05 to 1.34) 1.35 (1.19 to 1.52) 1.45 (1.28 to 1.65) 1.19 (1.03 to 1.39) 1.20 (1.07 to 1.34) 1.05 (0.92 to 1.19)
Diabetes-related cancere
 Case/person-year 24 484/4 064 614 497/47 943 302/35 324 331/31 364 310/27 237 223/22 612 400/40 195 357/37 232
 Multivariable adjusted model, HR (95% CI)b (Referent) 1.49 (1.36 to 1.63) 1.20 (1.06 to 1.34) 1.44 (1.28 to 1.61) 1.52 (1.35 to 1.70) 1.29 (1.13 to 1.48) 1.25 (1.12 to 1.39) 1.14 (1.01 to 1.28)
 Additionally adjusted for BMI, HR (95% CI)c (Referent) 1.40 (1.28 to 1.53) 1.12 (1.00 to 1.26) 1.34 (1.20 to 1.50) 1.41 (1.26 to 1.59) 1.21 (1.05 to 1.38) 1.16 (1.04 to 1.29) 1.05 (0.94 to 1.18)
Colorectal cancer
 Case/person-year 3275/4 083 317 66/48 325 41/35 547 48/31 608 45/27 450 42/22 767 48/40 484 48/37 485
 Multivariable adjusted model, HR (95% CI)b (Referent) 1.34 (1.05 to 1.72) 1.10 (0.80 to 1.51) 1.43 (1.07 to 1.92) 1.50 (1.10 to 2.03) 1.66 (1.20 to 2.28) 1.14 (0.85 to 1.54) 1.08 (0.79 to 1.48)
 Additionally adjusted for BMI, HR (95% CI)c (Referent) 1.25 (0.98 to 1.60) 1.02 (0.75 to 1.40) 1.33 (0.99 to 1.79) 1.39 (1.02 to 1.89) 1.54 (1.12 to 2.12) 1.05 (0.78 to 1.42) 1.00 (0.73 to 1.38)
Lung cancer
 Case/person-year 3455/4 084 133 62/48 353 44/35 550 49/31 616 42/27 461 36/22 788 71/40 483 55/37 500
 Multivariable adjusted model, HR (95% CI)b (Referent) 1.23 (0.95 to 1.58) 1.13 (0.83 to 1.52) 1.35 (1.01 to 1.81) 1.31 (0.96 to 1.79) 1.25 (0.90 to 1.76) 1.28 (1.00 to 1.65) 0.99 (0.75 to 1.32)
 Additionally adjusted for BMI, HR (95% CI)c (Referent) 1.28 (0.99 to 1.65) 1.18 (0.87 to 1.60) 1.43 (1.07 to 1.92) 1.37 (1.00 to 1.87) 1.32 (0.94 to 1.85) 1.36 (1.06 to 1.75) 1.05 (0.79 to 1.40)
Pancreatic cancer
 Case/person-year 874/4 085 780 39/48 368 15/35 575 25/31 640 21/27 479 20/22 800 24/40 516 31/37 520
 Multivariable adjusted model, HR (95% CI)b (Referent) 2.91 (2.10 to 4.04) 1.43 (0.85 to 2.40) 2.48 (1.64 to 3.73) 2.36 (1.51 to 3.68) 2.48 (1.57 to 3.92) 1.52 (0.99 to 2.33) 1.76 (1.17 to 2.65)
 Additionally adjusted for BMI, HR (95% CI)c (Referent) 2.82 (2.03 to 3.92) 1.37 (0.81 to 2.31) 2.38 (1.58 to 3.61) 2.30 (1.47 to 3.60) 2.41 (1.52 to 3.81) 1.46 (0.95 to 2.25) 1.67 (1.11 to 2.52)
Breast cancer
 Case/person-year 12 064/3 172 217 211/34 162 134/25 748 147/23 168 129/20 327 69/17 051 170/30 982 153/32 132
 Multivariable adjusted model, HR (95% CI)b (Referent) 1.44 (1.26 to 1.66) 1.21 (1.01 to 1.44) 1.48 (1.25 to 1.75) 1.47 (1.23 to 1.76) 0.93 (0.73 to 1.19) 1.26 (1.06 to 1.48) 1.13 (0.94 to 1.34)
 Additionally adjusted for BMI, HR (95% CI)c (Referent) 1.40 (1.22 to 1.61) 1.17 (0.98 to 1.40) 1.44 (1.21 to 1.71) 1.43 (1.19 to 1.71) 0.91 (0.71 to 1.16) 1.22 (1.04 to 1.44) 1.10 (0.92 to 1.31)
Endometrial cancer
 Case/person-year 1799/3 181 864 55/34 343 34/25 834 30/23 283 30/20 422 24/17 101 43/31 095 25/32 266
 Multivariable adjusted model, HR (95% CI)b (Referent) 2.25 (1.71 to 2.97) 1.82 (1.28 to 2.59) 1.74 (1.19 to 2.54) 1.92 (1.31 to 2.80) 1.81 (1.18 to 2.77) 1.68 (1.20 to 2.36) 0.97 (0.63 to 1.50)
 Additionally adjusted for BMI, HR (95% CI)c (Referent) 1.63 (1.24 to 2.15) 1.30 (0.91 to 1.86) 1.22 (0.84 to 1.78) 1.34 (0.91 to 1.96) 1.24 (0.81 to 1.90) 1.14 (0.81 to 1.60) 0.65 (0.42 to 1.01)
a

Only cancers that showed associations with incident type 2 diabetes in Table 2 were presented. Estimates were meta-analyzed using a random-effect model. BMI = body mass index; CI = confidence interval; HPFS = Health Professionals Follow-up Study; HR = hazard ratio; NHS = Nurses’ Health Study.

b

Adjusting for age (month), ethnicity (White, African American, Asian, others), smoking status (never smoked, past smoker, currently smoke 1-14 cigarettes per day, 15-24 cigarettes per day, or ≥25 cigarettes per day), alcohol intake (0, 0.1-4.9, 5.0-9.9, 10.0-14.9, 15.0-29.9, and ≥30.0 g/d), multivitamin use (yes, no), physical activity (quintiles), total energy (quintiles), alternative healthy eating index (quintiles), family history of diabetes (yes, no), family history of cancer (yes, no), endoscopy screening (yes, no), and fasting glucose screening (yes, no). For women, insulin use (yes, no), oral hypoglycemic drug use (yes, no), mammography screening, postmenopausal hormone use (never, former, or current hormone use, or missing), and oral contraceptive use were further adjusted.

c

Cumulative-averaged BMI (calculated as weight in kilograms divided by height in meters squared) (<21.0, 21.0-22.9, 23.0-24.9, 25.0-26.9, 27.0-29.9, 30.0-32.9, 33.0-34.9, or ≥35.0 kg/m2) was additionally adjusted.

d

Including esophagus cancer, liver cancer, kidney cancer, myeloma, pancreatic cancer, colorectal cancer, gallbladder cancer, postmenopausal breast cancer, ovarian cancer, and thyroid cancer.

e

Including thyroid cancer, breast cancer, liver cancer, pancreatic cancer, endometrial cancer, esophagus cancer, colorectal cancer, kidney cancer, gallbladder cancer, ovarian cancer, non-Hodgkin lymphoma, leukemia, and bladder cancer.