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DAAM2 knockdown augmented podocyte function. (A) DAAM2 was successfully knocked down in primary cultured podocyte by siRNA. Synaptopodin and cleaved caspase-3 increased in DAAM2-KD cells (siDAAM2) versus WT cells (siNC). (B) DAAM2 knockdown increased WT1 mRNA. (C) DAAM2 knockdown enhanced podocyte adhesion to collagen I–coated plates. (D) Migration was reduced in siDAAM2 versus siNC podocytes. * means p < 0.05; ** means p < 0.01; *** means p < 0.001 and **** means p < 0.0001.
